Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 39395..41179 Replicon plasmid pLG50
Accession NZ_CP084378
Organism Lactococcus garvieae strain Lg-Granada

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag LA387_RS11055 Protein ID WP_107106298.1
Coordinates 39395..40327 (-) Length 311 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag LA387_RS11060 Protein ID WP_107106297.1
Coordinates 40343..41179 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA387_RS11035 35410..36126 + 717 WP_225667050.1 hypothetical protein -
LA387_RS11170 36294..36419 + 126 WP_263867710.1 hypothetical protein -
LA387_RS11040 36544..37308 + 765 WP_225667051.1 abortive infection protein -
LA387_RS11045 37442..38392 - 951 WP_225667052.1 hypothetical protein -
LA387_RS11050 38406..38957 - 552 WP_225667053.1 recombinase family protein -
LA387_RS11055 39395..40327 - 933 WP_107106298.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LA387_RS11060 40343..41179 - 837 WP_107106297.1 hypothetical protein Antitoxin
LA387_RS11065 42119..42259 + 141 WP_107106296.1 type I toxin-antitoxin system Fst family toxin -
LA387_RS11070 42420..43598 - 1179 WP_225667054.1 protein kinase family protein -
LA387_RS11075 43686..44243 - 558 WP_107106295.1 recombinase family protein -
LA387_RS11080 44643..44828 + 186 WP_225667055.1 hypothetical protein -
LA387_RS11085 44860..45159 + 300 WP_225667057.1 hypothetical protein -
LA387_RS11090 45253..45465 + 213 WP_165719065.1 garvicin Q family class II bacteriocin -
LA387_RS11095 45489..45803 + 315 WP_032495339.1 bacteriocin immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..50557 50557
- flank IS/Tn - - 38406..38957 551


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(30-234)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 36228.16 Da        Isoelectric Point: 5.3574

>T218482 WP_107106298.1 NZ_CP084378:c40327-39395 [Lactococcus garvieae]
MKMTRLRDLIASQPGITSADNYQIRYAIDRFLARLVKSKYKENFVIKGGFLQGVIYNLDQRATRDLDASVRDMKANYTAI
EKAVLEICSIHLNDNVSFKLRSLESSQEGRIYSGFRAKLTMSFLEERTKINFDLDIGVGDEITPRAQKIEFPLLFSEEKG
KTETIEIFGYPRQTSQAEKLETILVRGLSNSRMKDFYDMHLFYNDLESISVHQSCEAFVKTWEFRHPETEINEELFLDWF
DLLEDISSNKKFLNDYWPNYTKDKPFASPLSFKDIVQEIIELLKSIQEEYLTNKGEKYARDKSSDTKEKL

Download         Length: 933 bp

>T218482 NZ_CP115992:c2337311-2337216 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 32659.68 Da        Isoelectric Point: 9.0976

>AT218482 WP_107106297.1 NZ_CP084378:c41179-40343 [Lactococcus garvieae]
MDIYKISNINLDEQNKKNLKRVAENMLSTFDEEQLQSIIKVMMTPFYQNELSSYLIEKTLPAIGSEEFNFLLLANKYNGH
IIRKIVKEEGISDYYLRKFVEKYSLKELIKGSYIFPNKPVDYLFVLQQRYKITAVSHETALYMQELIDYIPQVITISIPE
KYNADLIYNSFVQNSFLNNELNFLKKLGDNRITFVKNKPIPPSQIIELADENGLPLRVTSAERSVVDILKSSYKADEEVK
EQAVNSFIRRFPERIARLRRIAKNQNSLKELENYLLRY

Download         Length: 837 bp

>AT218482 NZ_CP115992:2337117-2337181 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References