Detailed information of TA system TA218479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2290982..2292555
• Replicon: chromosome
• Accession: NZ_CP084350
• Organism: Aeromonas caviae strain 71442

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LEO79_RS10510
• Protein ID: WP_201915019.1
• Coordinates: 2290982..2292301 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LEO79_RS10515
• Protein ID: WP_017410478.1
• Coordinates: 2292301..2292555 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LEO79_RS10495 (LEO79_10495)	2286894..2287658	+	765	WP_010672275.1	ATP-binding cassette domain-containing protein	-
LEO79_RS10500 (LEO79_10500)	2287690..2288583	+	894	WP_226044902.1	ABC transporter substrate-binding protein	-
LEO79_RS10505 (LEO79_10505)	2288580..2290562	+	1983	WP_226043569.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
LEO79_RS10510 (LEO79_10510)	2290982..2292301	-	1320	WP_201915019.1	type II toxin-antitoxin system HipA family toxin	Toxin
LEO79_RS10515 (LEO79_10515)	2292301..2292555	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
LEO79_RS10520 (LEO79_10520)	2293251..2294264	-	1014	WP_000845039.1	class 1 integron integrase IntI1	-
LEO79_RS10525 (LEO79_10525)	2294409..2294906	+	498	WP_001083725.1	trimethoprim-resistant dihydrofolate reductase DfrA12	-
LEO79_RS10530 (LEO79_10530)	2295018..2295308	+	291	WP_001336345.1	DUF1010 domain-containing protein	-
LEO79_RS10535 (LEO79_10535)	2295314..2296152	+	839	Protein_2039	AadA family aminoglycoside 3''-O-nucleotidyltransferase	-
LEO79_RS10540 (LEO79_10540)	2296269..2296616	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
LEO79_RS10545 (LEO79_10545)	2296610..2297449	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49566.54 Da
• Isoelectric Point: 6.8810

>T218479 WP_201915019.1 NZ_CP084350:c2292301-2290982 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGTHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T218479 NZ_CP115992:1891999-1892139 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT218479 WP_017410478.1 NZ_CP084350:c2292555-2292301 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT218479 NZ_CP115992:c1891997-1891854 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA