Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3361444..3363037 Replicon chromosome
Accession NZ_CP084349
Organism Aeromonas dhakensis strain 71453

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LEO73_RS15180 Protein ID WP_226008782.1
Coordinates 3361721..3363037 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LEO73_RS15175 Protein ID WP_041202615.1
Coordinates 3361444..3361737 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEO73_RS15160 (LEO73_15160) 3356910..3357716 + 807 WP_226008780.1 tryptophan synthase subunit alpha -
LEO73_RS15165 (LEO73_15165) 3359171..3360103 + 933 WP_005302905.1 hypothetical protein -
LEO73_RS15170 (LEO73_15170) 3360621..3361163 - 543 WP_226008781.1 metal-dependent hydrolase -
LEO73_RS15175 (LEO73_15175) 3361444..3361737 + 294 WP_041202615.1 helix-turn-helix domain-containing protein Antitoxin
LEO73_RS15180 (LEO73_15180) 3361721..3363037 + 1317 WP_226008782.1 HipA domain-containing protein Toxin
LEO73_RS15185 (LEO73_15185) 3363136..3363378 + 243 WP_005302916.1 DUF3297 family protein -
LEO73_RS15190 (LEO73_15190) 3363576..3364118 + 543 WP_226008783.1 beta/gamma crystallin-related protein -
LEO73_RS15195 (LEO73_15195) 3364188..3364631 - 444 WP_226008784.1 inhibitor of vertebrate lysozyme family protein -
LEO73_RS15200 (LEO73_15200) 3364813..3366024 - 1212 WP_010633406.1 NupC/NupG family nucleoside CNT transporter -
LEO73_RS15205 (LEO73_15205) 3366507..3367661 + 1155 WP_201891922.1 YdcF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49586.64 Da        Isoelectric Point: 5.9751

>T218478 WP_226008782.1 NZ_CP084349:3361721-3363037 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRSRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLLKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNYDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFSQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVERRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

>T218478 NZ_CP115992:1891698-1891880 [Enterococcus faecalis]
ATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTT
GTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGATTTGATTGCGCTGATTGTGAAATTGC
TTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10570.25 Da        Isoelectric Point: 6.2983

>AT218478 WP_041202615.1 NZ_CP084349:3361444-3361737 [Aeromonas dhakensis]
MTDTPLPTGTKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVMSSYSQPEVGDDEWF

Download         Length: 294 bp

>AT218478 NZ_CP115992:c1891997-1891813 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAATCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References