Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3580521..3581193 Replicon chromosome
Accession NZ_CP084343
Organism Yersinia pestis strain 20

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag LDH65_RS16240 Protein ID WP_002215144.1
Coordinates 3580521..3580946 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag LDH65_RS16245 Protein ID WP_002209939.1
Coordinates 3580927..3581193 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH65_RS16215 (LDH65_16200) 3576420..3577427 - 1008 Protein_3149 two-component system sensor histidine kinase CreC -
LDH65_RS16220 (LDH65_16205) 3577495..3578277 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
LDH65_RS16225 (LDH65_16210) 3578274..3579296 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -
LDH65_RS16230 (LDH65_16215) 3579382..3579798 - 417 Protein_3152 two-component system sensor histidine kinase CreC -
LDH65_RS16235 (LDH65_16220) 3579823..3580521 - 699 WP_002209937.1 two-component system response regulator CreB -
LDH65_RS16240 (LDH65_16225) 3580521..3580946 - 426 WP_002215144.1 protein YgfX Toxin
LDH65_RS16245 (LDH65_16230) 3580927..3581193 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
LDH65_RS16250 (LDH65_16235) 3581510..3582502 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
LDH65_RS16255 (LDH65_16240) 3582575..3583072 - 498 WP_002209941.1 DUF2165 family protein -
LDH65_RS16260 (LDH65_16245) 3583330..3584031 - 702 WP_002209942.1 hemolysin III family protein -
LDH65_RS16265 (LDH65_16250) 3584233..3585336 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T218476 WP_002215144.1 NZ_CP084343:c3580946-3580521 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T218476 NZ_CP115992:c1819738-1819595 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT218476 WP_002209939.1 NZ_CP084343:c3581193-3580927 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT218476 NZ_CP115992:1819494-1819621 [Enterococcus faecalis]
TGAAAAGAGAGCTGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACTTTTTGAATTATTTAAAAATAAC
CGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References