Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2689765..2690731 Replicon chromosome
Accession NZ_CP084343
Organism Yersinia pestis strain 20

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag LDH65_RS12230 Protein ID WP_002210981.1
Coordinates 2690273..2690731 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag LDH65_RS12225 Protein ID WP_002210982.1
Coordinates 2689765..2690211 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH65_RS12205 (LDH65_12200) 2685532..2686554 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -
LDH65_RS12210 (LDH65_12205) 2686623..2686995 + 373 Protein_2369 thiol peroxidase -
LDH65_RS12215 (LDH65_12210) 2687248..2687706 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
LDH65_RS12220 (LDH65_12215) 2687853..2689430 - 1578 WP_002210983.1 transcriptional regulator TyrR -
LDH65_RS12225 (LDH65_12220) 2689765..2690211 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
LDH65_RS12230 (LDH65_12225) 2690273..2690731 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
LDH65_RS12235 (LDH65_12230) 2690741..2691802 - 1062 WP_002210980.1 YcjF family protein -
LDH65_RS12240 (LDH65_12235) 2691799..2693196 - 1398 WP_002210979.1 YcjX family protein -
LDH65_RS12245 (LDH65_12240) 2693177..2693419 - 243 WP_002216375.1 phage shock protein PspD -
LDH65_RS12250 (LDH65_12245) 2693504..2693863 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
LDH65_RS12255 (LDH65_12250) 2693863..2694090 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
LDH65_RS12260 (LDH65_12255) 2694252..2694917 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T218474 WP_002210981.1 NZ_CP084343:2690273-2690731 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T218474 NZ_CP115992:c1756899-1756798 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAATGATAAAAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT218474 WP_002210982.1 NZ_CP084343:2689765-2690211 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT218474 NZ_CP115992:1756676-1756861 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAACGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCATTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References