Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2124252..2124898 Replicon chromosome
Accession NZ_CP084343
Organism Yersinia pestis strain 20

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag LDH65_RS09595 Protein ID WP_002214976.1
Coordinates 2124716..2124898 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag LDH65_RS09590 Protein ID WP_002211129.1
Coordinates 2124252..2124671 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH65_RS09570 (LDH65_09565) 2119323..2120318 + 996 WP_002211125.1 substrate-binding domain-containing protein -
LDH65_RS09575 (LDH65_09570) 2120384..2121961 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
LDH65_RS09580 (LDH65_09575) 2121964..2122986 + 1023 WP_002214974.1 ABC transporter permease -
LDH65_RS09585 (LDH65_09580) 2123035..2123994 + 960 WP_002211128.1 sugar kinase -
LDH65_RS09590 (LDH65_09585) 2124252..2124671 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDH65_RS09595 (LDH65_09590) 2124716..2124898 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
LDH65_RS09600 (LDH65_09595) 2125105..2125887 - 783 WP_002211130.1 flagellar biosynthetic protein FliR -
LDH65_RS09605 (LDH65_09600) 2125890..2126159 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
LDH65_RS09610 (LDH65_09605) 2126265..2127005 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
LDH65_RS09615 (LDH65_09610) 2127086..2127622 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
LDH65_RS09620 (LDH65_09615) 2127622..2128038 - 417 WP_002211134.1 flagellar motor switch protein FliN -
LDH65_RS09625 (LDH65_09620) 2128035..2129036 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
LDH65_RS09630 (LDH65_09625) 2129042..2129512 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T218473 WP_002214976.1 NZ_CP084343:c2124898-2124716 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T218473 NZ_CP115992:1536893-1537237 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAATAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGGCATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAAGCTGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT218473 WP_002211129.1 NZ_CP084343:c2124671-2124252 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT218473 NZ_CP115992:1536539-1536874 [Enterococcus faecalis]
ATGACAGTGTTTGATAGGATCAAATTATTAGCAAAAGAGAGAGGAAAATCCTTAAATCGAATCGAAGAAGAATTAGGTTT
ACCAAAAAATGTTCTGTATCGTATGAAAACTTCCGATAATCCTACTAAAGATAGACTAGAAACTTTAGCTAATTACTTTG
ATGTATCTGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAAATCTGATGATTTAGATGAT
GTACTGGATAACGTCATGAGCTTTGACGGTGAACCACTTGATGATCATGACAGAGAAGTTATCCGTGCATATTTAAAGGG
TAGATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References