Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
| Location | 33668..34202 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP084341 | ||
| Organism | Yersinia pestis strain 94 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q663N8 |
| Locus tag | LDH63_RS21665 | Protein ID | WP_002213360.1 |
| Coordinates | 33668..33967 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9ZGW3 |
| Locus tag | LDH63_RS21670 | Protein ID | WP_002224342.1 |
| Coordinates | 33960..34202 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDH63_RS21635 (LDH63_21610) | 29101..29526 | - | 426 | WP_002213267.1 | type III secretion system chaperone SycH | - |
| LDH63_RS21640 (LDH63_21615) | 29903..30301 | - | 399 | Protein_42 | ATP-binding protein | - |
| LDH63_RS21645 (LDH63_21620) | 30301..31473 | - | 1173 | WP_002220893.1 | IS21 family transposase | - |
| LDH63_RS21650 (LDH63_21625) | 31576..32220 | + | 645 | Protein_44 | IS3 family transposase | - |
| LDH63_RS21655 (LDH63_21630) | 32283..32675 | - | 393 | WP_002213403.1 | type III secretion system chaperone SycE/YerA | - |
| LDH63_RS21660 (LDH63_21635) | 32869..33528 | + | 660 | WP_002229754.1 | type III secretion system effector GTPase activator YopE | - |
| LDH63_RS21665 (LDH63_21640) | 33668..33967 | - | 300 | WP_002213360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LDH63_RS21670 (LDH63_21645) | 33960..34202 | - | 243 | WP_002224342.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LDH63_RS21675 (LDH63_21650) | 34368..34660 | - | 293 | Protein_49 | transposase | - |
| LDH63_RS21680 (LDH63_21655) | 34746..34919 | + | 174 | WP_002213357.1 | hypothetical protein | - |
| LDH63_RS21685 (LDH63_21660) | 35068..35304 | - | 237 | WP_154020274.1 | hypothetical protein | - |
| LDH63_RS21690 (LDH63_21665) | 35464..36429 | - | 966 | WP_002213354.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| LDH63_RS21695 (LDH63_21670) | 36426..37592 | - | 1167 | WP_002220902.1 | plasmid-partitioning protein SopA | - |
| LDH63_RS21700 (LDH63_21675) | 38060..38273 | + | 214 | Protein_54 | IS481 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | yscC / yscD / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA / yadA / yadA / sycH / sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB | 1..68337 | 68337 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11632.19 Da Isoelectric Point: 5.5114
>T218462 WP_002213360.1 NZ_CP084341:c33967-33668 [Yersinia pestis]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
Download Length: 300 bp
>T218462 NZ_CP115970:7737-7994 [Wohlfahrtiimonas chitiniclastica]
ATGCATGTATTCACATATACTGATGCTCGTAATAACTTAAAATCGGTTTTAGATAAAGTAGTTGATGATGCTGACGTTGC
ATTTATCACCAGAAAAGAAGGTGGCCATGCTGTGGTTATGGGCCAAGATCATTATAATAGTTTAATGGAAACACTTTACC
TTTTATCTTCACCAAATAATACTAATCGTTTGAATGAATCAATTGCTCAATTACGATCAGGTCAAGTTACAATAAGAGAA
TTAATCGAGGATGAATAG
ATGCATGTATTCACATATACTGATGCTCGTAATAACTTAAAATCGGTTTTAGATAAAGTAGTTGATGATGCTGACGTTGC
ATTTATCACCAGAAAAGAAGGTGGCCATGCTGTGGTTATGGGCCAAGATCATTATAATAGTTTAATGGAAACACTTTACC
TTTTATCTTCACCAAATAATACTAATCGTTTGAATGAATCAATTGCTCAATTACGATCAGGTCAAGTTACAATAAGAGAA
TTAATCGAGGATGAATAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8865.15 Da Isoelectric Point: 6.4781
>AT218462 WP_002224342.1 NZ_CP084341:c34202-33960 [Yersinia pestis]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
Download Length: 243 bp
>AT218462 NZ_CP115970:7987-8250 [Wohlfahrtiimonas chitiniclastica]
ATGAATAGTAGAAATATCGAATGGACTAGTAATTCTTGGGATGAATATATTTATTGGCAAACACAAGATAAAAAAATCCT
TAAACGTATTAATTCTTTAATTAAAGAGTGTCAAAGAACACCTTTTGAAGGTACTGGTAAACCAGAACCTTTAAAAGCTA
ATCTTTCTGGCTTTTGGAGCAGAAGAATAGATGAAAAACATCGCTTAGTATATGAAGTCACAGATGAAAAAATATCCATT
GTTCAATGTAGATTTCATTACTAA
ATGAATAGTAGAAATATCGAATGGACTAGTAATTCTTGGGATGAATATATTTATTGGCAAACACAAGATAAAAAAATCCT
TAAACGTATTAATTCTTTAATTAAAGAGTGTCAAAGAACACCTTTTGAAGGTACTGGTAAACCAGAACCTTTAAAAGCTA
ATCTTTCTGGCTTTTGGAGCAGAAGAATAGATGAAAAACATCGCTTAGTATATGAAGTCACAGATGAAAAAATATCCATT
GTTCAATGTAGATTTCATTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q663N8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1NQY6 |