Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2291190..2291836 Replicon chromosome
Accession NZ_CP084339
Organism Yersinia pestis strain 94

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag LDH63_RS10455 Protein ID WP_002214976.1
Coordinates 2291190..2291372 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag LDH63_RS10460 Protein ID WP_002211129.1
Coordinates 2291417..2291836 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH63_RS10420 (LDH63_10410) 2286576..2287046 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
LDH63_RS10425 (LDH63_10415) 2287052..2288053 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
LDH63_RS10430 (LDH63_10420) 2288050..2288466 + 417 WP_002211134.1 flagellar motor switch protein FliN -
LDH63_RS10435 (LDH63_10425) 2288466..2289002 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
LDH63_RS10440 (LDH63_10430) 2289083..2289823 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
LDH63_RS10445 (LDH63_10435) 2289929..2290198 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
LDH63_RS10450 (LDH63_10440) 2290201..2290983 + 783 WP_002211130.1 flagellar biosynthetic protein FliR -
LDH63_RS10455 (LDH63_10445) 2291190..2291372 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
LDH63_RS10460 (LDH63_10450) 2291417..2291836 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDH63_RS10465 (LDH63_10455) 2292094..2293053 - 960 WP_002211128.1 sugar kinase -
LDH63_RS10470 (LDH63_10460) 2293102..2294124 - 1023 WP_002214974.1 ABC transporter permease -
LDH63_RS10475 (LDH63_10465) 2294127..2295704 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
LDH63_RS10480 (LDH63_10470) 2295770..2296765 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T218451 WP_002214976.1 NZ_CP084339:2291190-2291372 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T218451 NZ_CP115955:3541193-3541444 [Ralstonia pseudosolanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT218451 WP_002211129.1 NZ_CP084339:2291417-2291836 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT218451 NZ_CP115955:3541441-3541854 [Ralstonia pseudosolanacearum]
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References