Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1660273..1661239 Replicon chromosome
Accession NZ_CP084339
Organism Yersinia pestis strain 94

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag LDH63_RS07540 Protein ID WP_002210981.1
Coordinates 1660273..1660731 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag LDH63_RS07545 Protein ID WP_002210982.1
Coordinates 1660793..1661239 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH63_RS07510 (LDH63_07510) 1656087..1656752 + 666 WP_002210975.1 phage shock protein PspA -
LDH63_RS07515 (LDH63_07515) 1656914..1657141 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
LDH63_RS07520 (LDH63_07520) 1657141..1657500 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
LDH63_RS07525 (LDH63_07525) 1657585..1657827 + 243 WP_002216375.1 phage shock protein PspD -
LDH63_RS07530 (LDH63_07530) 1657808..1659205 + 1398 WP_002210979.1 YcjX family protein -
LDH63_RS07535 (LDH63_07535) 1659202..1660263 + 1062 WP_002210980.1 YcjF family protein -
LDH63_RS07540 (LDH63_07540) 1660273..1660731 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
LDH63_RS07545 (LDH63_07545) 1660793..1661239 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
LDH63_RS07550 (LDH63_07550) 1661575..1663152 + 1578 WP_002210983.1 transcriptional regulator TyrR -
LDH63_RS07555 (LDH63_07555) 1663299..1663757 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
LDH63_RS07560 (LDH63_07560) 1664010..1664513 - 504 WP_002210984.1 thiol peroxidase -
LDH63_RS07565 (LDH63_07565) 1664676..1665650 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1663299..1663757 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T218450 WP_002210981.1 NZ_CP084339:c1660731-1660273 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T218450 NZ_CP115955:c3360988-3360575 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACGCCGCCAAGGCCGATACGGC
GGAAACGCTGCTGATGACAGGCGGTGTCGTCAGCGTACAGGTGCTGAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAAGCCGTGCGTGCGCAATGCCGGATCGAGCCGCTGACGCTCGAAACC
CATGAGCTCGGACGGCGTCTCGCAGAACGCTACGGACTGTCGGTCTATGACGCACTGATCGTCGCGGCCGCATTGCTTGC
CGGCTGCAACGTGCTGTATTCCGAGGACATGCAGCACGGCCTGGTGGTCGAGCAGCATCTGCGCATCGTCAATCCTTTTT
CGGCACGGGCATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT218450 WP_002210982.1 NZ_CP084339:c1661239-1660793 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT218450 NZ_CP115955:c3361208-3360975 [Ralstonia pseudosolanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCCATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAACTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGTTCCGCGCGCGAGCTGTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References