Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 715253..715873 Replicon chromosome
Accession NZ_CP084339
Organism Yersinia pestis strain 94

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag LDH63_RS03160 Protein ID WP_002208622.1
Coordinates 715253..715456 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag LDH63_RS03165 Protein ID WP_002218472.1
Coordinates 715505..715873 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH63_RS03130 (LDH63_03130) 710275..710613 + 339 WP_002208627.1 P-II family nitrogen regulator -
LDH63_RS03135 (LDH63_03135) 710653..711942 + 1290 WP_002228344.1 ammonium transporter AmtB -
LDH63_RS03140 (LDH63_03140) 712202..713062 - 861 WP_002208625.1 acyl-CoA thioesterase II -
LDH63_RS03145 (LDH63_03145) 713319..713840 + 522 WP_002208624.1 YbaY family lipoprotein -
LDH63_RS03150 (LDH63_03150) 713976..714365 - 390 WP_002208623.1 MGMT family protein -
LDH63_RS03160 (LDH63_03160) 715253..715456 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
LDH63_RS03165 (LDH63_03165) 715505..715873 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
LDH63_RS03170 (LDH63_03170) 716032..716385 - 354 WP_002208619.1 hypothetical protein -
LDH63_RS03175 (LDH63_03175) 717259..717402 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
LDH63_RS03180 (LDH63_03180) 717418..717678 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T218449 WP_002208622.1 NZ_CP084339:c715456-715253 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T218449 NZ_CP115955:2628481-2628756 [Ralstonia pseudosolanacearum]
ATGGAGGTCAAGTGGACTGGCAAAGCGGTATCGGACATCACGCGCCTGTACGAATTTCTCTCGCAGGTCAATAAGCCTGC
GGCTATCCGCGTAGTGCAGTCTCTGACTGGCGCACCGAAATCGTTGGTGGTGAACCCGCGTATTGGTGAGCAGTTAGATG
AGTTTGAGCCGCGTGAGGTTCGTCGCATCATCGTGGGTCAGTACGAGATGCGGTATGCGATTCGTGGTTCGGTCATTTAC
GTGCTGCGTTTGTGGCACACGCGCGAGGATCGCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT218449 WP_002218472.1 NZ_CP084339:c715873-715505 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT218449 NZ_CP115955:2628212-2628481 [Ralstonia pseudosolanacearum]
ATGGCTCATCTTGACACCCGCGTGCTTACCGCCCATGTGCCGGTACAGTTGGCGGAACGAGTCGATCAGATTGCGGAGCG
CCTTGAGCGGTCACGTGGTTGGATCATGAAACAAGCACTCTCTGCCTGGATCGATCAGGAAGAAGAGCGTAGCCGGTTGA
CGCGTGAGGCATTGGCCGATGTGGACGCAGGCACGGTGATCGACCATCAGGCCGTGCAAGCGTGGGCGGATAGCCTTTCG
ACAAGCAAACCGAAAAAGGCGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References