Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
| Location | 13422..13956 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP084338 | ||
| Organism | Yersinia pestis strain R | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q663N8 |
| Locus tag | LDH64_RS21715 | Protein ID | WP_002213360.1 |
| Coordinates | 13422..13721 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9ZGW3 |
| Locus tag | LDH64_RS21720 | Protein ID | WP_002224342.1 |
| Coordinates | 13714..13956 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDH64_RS21685 (LDH64_21645) | 8855..9280 | - | 426 | WP_002213267.1 | type III secretion system chaperone SycH | - |
| LDH64_RS21690 (LDH64_21650) | 9657..10055 | - | 399 | Protein_18 | ATP-binding protein | - |
| LDH64_RS21695 (LDH64_21655) | 10055..11227 | - | 1173 | WP_002220893.1 | IS21 family transposase | - |
| LDH64_RS21700 (LDH64_21660) | 11330..11974 | + | 645 | Protein_20 | IS3 family transposase | - |
| LDH64_RS21705 (LDH64_21665) | 12037..12429 | - | 393 | WP_002213403.1 | type III secretion system chaperone SycE/YerA | - |
| LDH64_RS21710 (LDH64_21670) | 12623..13282 | + | 660 | WP_002229754.1 | type III secretion system effector GTPase activator YopE | - |
| LDH64_RS21715 (LDH64_21675) | 13422..13721 | - | 300 | WP_002213360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LDH64_RS21720 (LDH64_21680) | 13714..13956 | - | 243 | WP_002224342.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LDH64_RS21725 (LDH64_21685) | 14122..14414 | - | 293 | Protein_25 | transposase | - |
| LDH64_RS21730 (LDH64_21690) | 14500..14673 | + | 174 | WP_002213357.1 | hypothetical protein | - |
| LDH64_RS21735 (LDH64_21695) | 14822..15058 | - | 237 | WP_154020274.1 | hypothetical protein | - |
| LDH64_RS21740 (LDH64_21700) | 15218..16183 | - | 966 | WP_002213354.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
| LDH64_RS21745 (LDH64_21705) | 16180..17346 | - | 1167 | WP_002220902.1 | plasmid-partitioning protein SopA | - |
| LDH64_RS21750 (LDH64_21710) | 17814..18027 | + | 214 | Protein_30 | IS481 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | yadA / yadA / sycH / sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP / yopO/ypkA | 1..68335 | 68335 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11632.19 Da Isoelectric Point: 5.5114
>T218448 WP_002213360.1 NZ_CP084338:c13721-13422 [Yersinia pestis]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE
Download Length: 300 bp
>T218448 NZ_CP115955:2535705-2536118 [Ralstonia pseudosolanacearum]
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8865.15 Da Isoelectric Point: 6.4781
>AT218448 WP_002224342.1 NZ_CP084338:c13956-13714 [Yersinia pestis]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV
Download Length: 243 bp
>AT218448 NZ_CP115955:2535457-2535708 [Ralstonia pseudosolanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q663N8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1NQY6 |