Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3184506..3185178 Replicon chromosome
Accession NZ_CP084336
Organism Yersinia pestis strain R

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag LDH64_RS14480 Protein ID WP_002215144.1
Coordinates 3184506..3184931 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag LDH64_RS14485 Protein ID WP_002209939.1
Coordinates 3184912..3185178 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH64_RS14460 (LDH64_14440) 3180179..3180697 + 519 WP_002209934.1 flavodoxin FldB -
LDH64_RS14465 (LDH64_14445) 3180787..3182244 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
LDH64_RS14470 (LDH64_14450) 3182365..3183783 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
LDH64_RS14475 (LDH64_14455) 3183808..3184506 - 699 WP_002209937.1 two-component system response regulator CreB -
LDH64_RS14480 (LDH64_14460) 3184506..3184931 - 426 WP_002215144.1 protein YgfX Toxin
LDH64_RS14485 (LDH64_14465) 3184912..3185178 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
LDH64_RS14490 (LDH64_14470) 3185495..3186487 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
LDH64_RS14495 (LDH64_14475) 3186560..3187057 - 498 WP_002209941.1 DUF2165 family protein -
LDH64_RS14500 (LDH64_14480) 3187315..3188016 - 702 WP_002209942.1 hemolysin III family protein -
LDH64_RS14505 (LDH64_14485) 3188218..3189321 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T218447 WP_002215144.1 NZ_CP084336:c3184931-3184506 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T218447 NZ_CP115955:2535457-2535708 [Ralstonia pseudosolanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT218447 WP_002209939.1 NZ_CP084336:c3185178-3184912 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT218447 NZ_CP115955:2535705-2536118 [Ralstonia pseudosolanacearum]
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGACGACG
CAGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
GACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGACTTGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References