Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 360739..361448 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID P9WF84
Locus tag BCG_RS01620 Protein ID WP_003401406.1
Coordinates 360739..361167 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4BRN8
Locus tag BCG_RS01625 Protein ID WP_011799093.1
Coordinates 361191..361448 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS01595 356606..357739 - 1134 WP_003401394.1 hypothetical protein -
BCG_RS01600 357736..358356 - 621 WP_003401397.1 TetR/AcrR family transcriptional regulator -
BCG_RS01605 358453..359034 + 582 WP_003401399.1 VOC family protein -
BCG_RS01610 358964..359689 - 726 WP_003902925.1 TetR/AcrR family transcriptional regulator -
BCG_RS01615 359779..360699 + 921 WP_003401404.1 DUF2236 domain-containing protein -
BCG_RS01620 360739..361167 - 429 WP_003401406.1 type II toxin-antitoxin system VapC family toxin Toxin
BCG_RS01625 361191..361448 - 258 WP_011799093.1 ribbon-helix-helix domain-containing protein Antitoxin
BCG_RS01630 361533..364283 - 2751 WP_011799094.1 PE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15887.27 Da        Isoelectric Point: 7.2214

>T21844 WP_003401406.1 NC_008769:c361167-360739 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Download         Length: 429 bp

>T21844 NC_008769:c361167-360739 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.32 Da        Isoelectric Point: 10.6530

>AT21844 WP_011799093.1 NC_008769:c361448-361191 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MRTTVSISDELLATAKRRARERGQSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNRVLSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT21844 NC_008769:c361448-361191 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGCGCACCACCGTGTCAATCTCCGATGAACTACTGGCTACCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGCACCGGCGGCGCCCGGCCAACCGTCCCCGTTTTTG
ACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATAGGGTGTTGTCCGAAGTGCTCGACGAGGGTCTGGAA
CTGAACTCGCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRN8

References