Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 716394..717014 Replicon chromosome
Accession NZ_CP084336
Organism Yersinia pestis strain R

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag LDH64_RS03165 Protein ID WP_002208622.1
Coordinates 716394..716597 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag LDH64_RS03170 Protein ID WP_002218472.1
Coordinates 716646..717014 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH64_RS03135 (LDH64_03130) 711416..711754 + 339 WP_002208627.1 P-II family nitrogen regulator -
LDH64_RS03140 (LDH64_03135) 711794..713083 + 1290 WP_002228344.1 ammonium transporter AmtB -
LDH64_RS03145 (LDH64_03140) 713343..714203 - 861 WP_002208625.1 acyl-CoA thioesterase II -
LDH64_RS03150 (LDH64_03145) 714460..714981 + 522 WP_002208624.1 YbaY family lipoprotein -
LDH64_RS03155 (LDH64_03150) 715117..715506 - 390 WP_002208623.1 MGMT family protein -
LDH64_RS03165 (LDH64_03160) 716394..716597 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
LDH64_RS03170 (LDH64_03165) 716646..717014 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
LDH64_RS03175 (LDH64_03170) 717173..717526 - 354 WP_002208619.1 hypothetical protein -
LDH64_RS03180 (LDH64_03175) 718400..718543 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
LDH64_RS03185 (LDH64_03180) 718559..718819 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T218435 WP_002208622.1 NZ_CP084336:c716597-716394 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T218435 NZ_CP115947:1841860-1842705 [Ralstonia solanacearum MolK2]
ATGAGCCGCAATCTCGCCGCTTCGATTCGGACCCGCCTGAAGCAGCACGCCGATGCCTCAAAGCAGGATTTCAACCTGAC
GCTCACCCAGTACGGGCTGGAGCGCCTGTTGTACCGACTGTCGATCTCGCAGCATGCCGCAAACTACCTGCTCAAGGGCG
CCCTGCTATTTGCCTTGTGGTACGACCAACCGCATCGGCCGACGCGAGACGCGGATCTACTTGGCTATGGCCCGGACGAC
ATCGACACCGCCGTCGCGGCTTTCCGCGAAATCAGCCGGATCGAAGTTGAAGACGGCATCGCCTTCGAACCTGCCTCGAT
CAGGGGCTTGGAAATCCGTAAAGAAACGGGCTATGGCGGCGTGCGAATCGACCTGCAGGCGAAACTGGATGGTGCACGCA
TCGCGCTGCAGGTGGACATCGGCTTTGGGGACGCAGTCACACCAGCACCCGAGACCGTCGACTACCCGACGCTACTCGAC
AATTTGCCGGCACCGCGGTTGCGGGCCTATCCCAAACACACCGTAGTCGCCGAAAAACTCCACGCGGTGTGCCTGCTGGG
CATGGCCAACACACGCATGAAGGACTACTTCGATCTCTGGGTGCTGCTAACCGAAGATACCTTGGACCCCGGGGAACTAC
GCCGCGCTGCACAAGCCACGTTCACCCGCCGAGGGCTCGCCATCCCTGAGGCGACCCCTGCGGGCTTGAGCGACACCTTT
GCCCGGGATGCAACGAAGCAGCAGCAGTGGGCTGCCTTCCTGAAGAAGAACCGCCTGCCGGCGATGGACCTCGCCCAAGT
CGTAGCACTGCTGCGCAACGCGTTCCAGCACCTTCAAGCCCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT218435 WP_002218472.1 NZ_CP084336:c717014-716646 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT218435 NZ_CP115947:1841249-1841863 [Ralstonia solanacearum MolK2]
ATGACTCTCCCCCACCAGACGCTCGAACAAGCCGTCCTGGCGCTCGCCGAGCGCCAGCCGCTACTGCGCGCTCGTGATCT
GGCCAAACGGGGACTGCCAACGATGGTGCTCAGCCGGCTCGTCGCGGCCGGCAAGCTGGAACGCATCGCCCGAGGCATCT
ACAGCCTGCAAGGACGCGCGCTCGGCGAGCACCGCTCCCTGGCCGAGTCCGCCCTGCGTGTGCCGCGTGGAGTGGTCTGC
CTGCTGTCGGCGCTGCGTGTCCACGGCATCGGCACACAGGCCCCCTTCGAGGTCTGGATGGCGATCCCCCCGCACACACC
CACACCGAGCCTCGACCAGCCGGCACTGCGCGTGGTTCGCATGTCGGGCGCAGCCATGACCGAAGGCATCGAGCATGTTG
AAATCGATGGCGTGCCGGTGCCGCTGTTCAACCTGGACAAGACGGTGGCGGACTGCTTCAAGTACCGAAACAAGATCGGC
CTGGACGTAGCATTGGAAGCACTGCGCGATGGATGGTCGCAGCGCAGGCTCACGATGGACCGACTCTGGCATTACGCCAC
GATCAACCGTGTGACCAACGTCATGCGCCCCTATCTGGAGAGCGTGACCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References