Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 151909..152825 Replicon plasmid pHS18-89
Accession NZ_CP084322
Organism Pseudomonas aeruginosa strain HS18-89

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag LEL82_RS33810 Protein ID WP_019437783.1
Coordinates 151909..152433 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag LEL82_RS33815 Protein ID WP_019437782.1
Coordinates 152430..152825 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL82_RS33790 (LEL82_33755) 147761..148375 + 615 Protein_147 glycerate kinase -
LEL82_RS33795 (LEL82_33760) 148795..148986 - 192 WP_019437785.1 hypothetical protein -
LEL82_RS33800 (LEL82_33765) 149361..150416 + 1056 WP_139139567.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
LEL82_RS33805 (LEL82_33770) 150613..151863 + 1251 WP_019437784.1 TerD family protein -
LEL82_RS33810 (LEL82_33775) 151909..152433 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
LEL82_RS33815 (LEL82_33780) 152430..152825 - 396 WP_019437782.1 hypothetical protein Antitoxin
LEL82_RS33820 (LEL82_33785) 153409..155292 - 1884 WP_223819158.1 helicase -
LEL82_RS33825 (LEL82_33790) 155492..155746 + 255 WP_021263738.1 hypothetical protein -
LEL82_RS33830 (LEL82_33795) 156640..157164 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrVC1 / ARR-3 / dfrA22 / qacE / sul1 / mph(E) / msr(E) / cmlA1 / ant(2'')-Ia / aac(6')-Il / blaNDM-14 / dfrA27 / blaOXA-246 / aac(6')-IIa - 1..463412 463412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T218434 WP_019437783.1 NZ_CP084322:c152433-151909 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T218434 NZ_CP115947:1788662-1789075 [Ralstonia solanacearum MolK2]
TTGAGTTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAACCCGATGCGCGCGTGCTCGCCTGGATGCA
AGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGTAAAGGCATCGAGCGGCTGGACGACG
CGGCACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTTGACATCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCTGCGATCGATGGCCTGCTCGCCGC
AACCGCCCTGCAGCACGACCTCATCCTGGTCACGCGTAACACGAAGGATTTCGTCGGACTCGATGTCCCGCTCATCAACC
CTTGGGAAACGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT218434 WP_019437782.1 NZ_CP084322:c152825-152430 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT218434 NZ_CP115947:1788414-1788665 [Ralstonia solanacearum MolK2]
ATGCAAAGCTGGCAATTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCAGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTCGCGGTTGTGATCTCGCGCGCACTGTTCGATCGCCTGAGTGGCGGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGACGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References