Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4757674..4758932 Replicon chromosome
Accession NZ_CP084321
Organism Pseudomonas aeruginosa strain HS18-89

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag LEL82_RS22185 Protein ID WP_003112528.1
Coordinates 4757674..4758429 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag LEL82_RS22190 Protein ID WP_003086329.1
Coordinates 4758564..4758932 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL82_RS22175 (LEL82_22145) 4752847..4755390 + 2544 WP_031755663.1 acyl-homoserine-lactone acylase QuiP -
LEL82_RS22180 (LEL82_22150) 4755545..4756906 - 1362 WP_073647918.1 DNA recombination protein RmuC -
LEL82_RS22185 (LEL82_22155) 4757674..4758429 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
LEL82_RS22190 (LEL82_22160) 4758564..4758932 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
LEL82_RS22195 (LEL82_22165) 4759005..4760291 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
LEL82_RS22200 (LEL82_22170) 4760347..4761840 - 1494 WP_031755661.1 aldehyde dehydrogenase family protein -
LEL82_RS22205 (LEL82_22175) 4762015..4762491 + 477 WP_003112531.1 hypothetical protein -
LEL82_RS22210 (LEL82_22180) 4762494..4762769 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T218430 WP_003112528.1 NZ_CP084321:c4758429-4757674 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T218430 NZ_CP115946:1977639-1978985 [Ralstonia solanacearum MolK2]
ATGGGGCGCCGGTCGCATACGCGGGCCCTCGGGCTCTGGATGAATGGCACCCATGTCGGCCGCTGGGAGCTGCACCCGCA
TCAGGGCGACGTGCTGAAGTACGCGGCATCCTGGGTGGCCGCGCCCGAGGGGCGGCCCCTGTCGCTGTCCCTGCCGTTCA
CGCCAGACAACGCGCCCCACAAGGGCCCGGCGGTCCGGGCGTATTTCGAGAACCTCCTGCCGGACAGCCGCGACATCCGC
GAGCGCATCGCGCGCCGTTTCCAGGCCGGGACAACCGAGGCGTTCGACCTGCTGGAGCAGATCGGCCGCGACTGCATCGG
CGCCCTGCAAGTGCTGCCGGCCGACATGGCCCCACCGGCCACGGGCGACATCGACGCGGAACCGCTGACCGAGGCGCAGA
TCGCGCAGACGCTGCGGGAGACCGTCGCCCCGCCGCCCTTGGGCGGCATGCCGGAAGACGATGGCCATTTCCGCATCTCG
ATCGCCGGCGCGCAGGAAAAGACGGCCTTCCTCCAGATCGACGGACACTGGTACCGCCCCCGGGGCGCGACGCCGACCAG
CCACATCTTCAAGCTGCCGATGGGGCTGGTCGGCAACATGCAGCTGGACCTGAGCGAGTCGGTGGAAAACGAATGGCTGT
GCGCCCTGGTGCTGCGGGCGTATGGCCTGCCCGTCGCGCACTGCCGGCCGCTGGTGTTCGAAGACCAGAAGGTGCTCGCC
GTGGAGCGGTTCGACCGCATGTGGTGGGACCGCGGCGGCAAACGGCTCATCCGCCTGCCGCAGGAAGACATGTGCCAGGC
CACGGCGACGCCCCCGCACCTGAAGTACGAGGCCGACGGCGGCCCCGGCATCGACCGCATCATGGGCCTGCTCGACGGCT
CCGCGCACCGGGAAGCCGACCGCCTGACGCTGTTCCGCAGCCAGGTGCTGTTCTGGATGCTGCGCGCGCCCGATGGCCAT
GCGAAGAACTTCAGCCTCGCGCTGCGTCCCGGCGGCGCCTACGCGCTCACGCCGCTGTACGACGTGATGTCGGCCTACCC
GCTGCTGGGCGAGGGGCCGGGCAAGCTTTCGCCGCACCGGATCCGGCTGGCGATGGCCGTCCGCTCGAAGAATGCGCACT
GGAAAATGCAGGACATCCAGCGGCGCCACTGGCTGGGCCTGGGCCAACGCTACGGCATCGTCACGTCCGATGGCGCGGAT
GCCGCCTCCATCGTGGACAACCTGGTGGCCCGGACGCCCGAGGTGACCCGTACCGTGCGCGCGATGCTGCCGGAAGGCTT
CCCGCAGCCGCTGGCCGACCGCATTCTGCAGGGGCTGCGGCACGCCGCGGACAAACTCGCGGGATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT218430 WP_003086329.1 NZ_CP084321:c4758932-4758564 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT218430 NZ_CP115946:1977368-1977634 [Ralstonia solanacearum MolK2]
ATGAACGAGTTCATCGTACGCACCCCCGAGCAGTTGCCGGCGATCCTCAAGGGTTTCCGCAAACAGGCCGGGCTGAGCCA
GGCCGAACTGGCCGCCCGGATGGGCATGCGCCAGCAAACCCTCTCCGCGTTGGAGCGCAACGCAGAAAACGTGAGCGCCG
GGCGGCTGATGCGCCTGCTGTCGGTGCTGGGCGTGGAGCTGGTGCTGCGCAAACCCGACGCCGCCGGCGAGCCCGGCCGC
CCGGCGTCCGACCAGCCGCAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References