Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4071136..4072356 Replicon chromosome
Accession NZ_CP084321
Organism Pseudomonas aeruginosa strain HS18-89

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LEL82_RS18865 Protein ID WP_003160088.1
Coordinates 4071778..4072356 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LEL82_RS18860 Protein ID WP_003088112.1
Coordinates 4071136..4071690 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL82_RS18835 (LEL82_18815) 4066704..4067255 + 552 WP_003132721.1 XRE family transcriptional regulator -
LEL82_RS18840 (LEL82_18820) 4067252..4067650 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LEL82_RS18845 (LEL82_18825) 4067663..4067986 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LEL82_RS18850 (LEL82_18830) 4068317..4068778 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LEL82_RS18855 (LEL82_18835) 4068783..4070978 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LEL82_RS18860 (LEL82_18840) 4071136..4071690 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LEL82_RS18865 (LEL82_18845) 4071778..4072356 + 579 WP_003160088.1 HD domain-containing protein Toxin
LEL82_RS18870 (LEL82_18850) 4072465..4073652 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LEL82_RS18875 (LEL82_18855) 4073642..4075813 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
LEL82_RS18880 (LEL82_18860) 4075803..4077080 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaKPC-2 - 4063653..4100813 37160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T218429 WP_003160088.1 NZ_CP084321:4071778-4072356 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T218429 NZ_CP115946:1432508-1432783 [Ralstonia solanacearum MolK2]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGATGTGGCGCGCCTGTATGAATTCCTGGCCCCTGTCAACAAGCCAGC
CGCCGCTCGGGCAGTGCAAGCGCTGATCAAGGCCTCGACCATTTTGCTGACCAACCCGCGCGTTGGCGAACAACTATTTC
AGTTCGAGCCGCGCGAGGTGCGTCGGATTCTGGTCGGCCAGTACGAGATGCGCTACGCACTCCAGGACGAGACGATCTAC
GTGCTGCGGCTGTGGCACACCAGGGAGGATCGATAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT218429 WP_003088112.1 NZ_CP084321:4071136-4071690 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT218429 NZ_CP115946:1432239-1432508 [Ralstonia solanacearum MolK2]
ATGCCTAAAGCCGAAACACGCGTGCTGACCGCGCACGTTCCCGTTCCCCTTGCCGAGAAAGTTGACCAATTGGCTGAGCG
CCTCGAACGCTCGCGCGGCTGGATCATGAAACAGGCGCTCTCGGCTTGGATCGGCCAGGAGGAAGAGCGCGACCGCTTGA
CCCACGAGGCGCTGGCTGACATGGATGCCGGCCGCGTCATCGACCATCAGGCTGTTCAGGCATGGGCGGATAGCCTGAGC
ACTGACGAACCGCTGCAGGTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References