Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1897596..1899104 Replicon chromosome
Accession NZ_CP084321
Organism Pseudomonas aeruginosa strain HS18-89

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag LEL82_RS08900 Protein ID WP_003119682.1
Coordinates 1897596..1898183 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag LEL82_RS08905 Protein ID WP_003119683.1
Coordinates 1898250..1899104 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LEL82_RS08895 (LEL82_08885) 1893851..1897330 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LEL82_RS08900 (LEL82_08890) 1897596..1898183 + 588 WP_003119682.1 GNAT family protein Toxin
LEL82_RS08905 (LEL82_08895) 1898250..1899104 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
LEL82_RS08910 (LEL82_08900) 1899201..1901364 + 2164 Protein_1767 TonB-dependent receptor family protein -
LEL82_RS08915 (LEL82_08905) 1901539..1903413 + 1875 WP_003091605.1 MFS transporter -
LEL82_RS08920 (LEL82_08910) 1903474..1903683 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T218428 WP_003119682.1 NZ_CP084321:1897596-1898183 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T218428 NZ_CP115945:1705936-1706583 [Ralstonia syzygii R24]
ATGGCGAACTACCAACGGCTGAACGCCGAGAACGCGTATATCTGGCGGATCGTCCATCGCCAGAACATACCGTGGATTCT
GGACCATGGGCTGGTATGCGCAAATAGCGAACGGCTTGACCCAAATTTTGTGCCGATCGGCAACGCTGACCTGATCGATC
GCCGCGCGCACCGCGTCGTGCCAATTGCGCCCGGCGGAACGTTGAGTGACTACGTGCCGTTTTATTTCACCCCGTTCTCG
CCAATGATGTACAACATCTACACTGGTCGGACCGTACGCCAGCAGCGCAACGAAGACATCTGCATGCTGGTCAGCACGTT
GCCGGTTTTGCGACAGTTGGGCATTCCGTTCGTGTTTACCGATCGGCATGCATATACGCAGTTGGCCCGCTTTTTCAGCG
ATCTGGGTGATCTTGACCAAGTCGACTGGCCTCTTCTGCAGGCGCGCAACTTCAAGCGAAACCCGGACGATCCGGAGCAA
ATCGAACGATATCAGGCCGAGACCCTAGTACACCGGCATCTTCCGGTGACTGGACTCACTGCCATCGTATGCTACAACGA
AGAGGTGAAACGGGAGTTGGAGCAATTGGCGGCCGCGCGCCGCTTGAATGTAACGGTGCAGGCACTTCCCAATTGGTACT
TCCAATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT218428 WP_003119683.1 NZ_CP084321:1898250-1899104 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT218428 NZ_CP115945:1706580-1707665 [Ralstonia syzygii R24]
ATGATTACGTACACCCAAGGCAACCTTCTGGATGCGCCGGCGGAAGCGCTCGTCAACACAGTCAACACCGTCGGCGTAAT
GGGAAAAGGCATCGCGCTGATGTTCAAGGAGAAATTCCCCGAGAACTTCCGCGAATATGTGGCCGCTTGCAAAGAAGGTC
GTGTGCAGACCGGCAAGATGTTCGTCACGGAACGCATGGCTCTGATCGGGCCGAAGTGGATCGTCAATTTTCCGACCAAG
CAACATTGGCGTTCGCCTTCGCGGCTCGAGTGGATCGTCGACGGGCTGAAGGAGCTGCGCCATTTCATTGAACGGGAGCA
CGTCCGGTCGATAGCGATTCCCCCACTTGGTGCGGGCAACGGCAGTTTGGACTGGCCGCTCGTGAAGGCCGCAATCGACG
CAGCGCTAGGCGACCTGGGCGGTACCGAGGTTTTCGTGTACGAACCGACCGCGAAATACCAGAATGTCGCGAAGCGTGAG
GGCGTGGAAAAGCTGACACCGGCGCGAGCGCTGATTGCCGAGCTGGTGCGCCGCTACTGGATTCTCGGAATGGACTGCAG
TCTGCTCGAAATCCAGAAGTTGGCATGGTTCCTCGAGCGTGTCATCGAACGCACCGATGCGCCGAACCCGCTTCAGTTGA
AGTTCGTTGCTCACACGTACGGTCCATACGCGAATCGGCTGGATCACCTGCTGAACAACCTCGACGGCAGCTATTTGCAC
TGCGACAAGCGCATTGCGGATGCCGGGCCGCTCGACGTCATTTGGTTCGATGATCGTCGCAGCGATATGCTTGCCGCATA
CTTGAAAAGCGGCGAGATGAAGCCGTACCTGCGTGCGCTCGAAGAGACTACGTCGCTGATCGACGGATTTGAATCGCCGT
TCGGACTCGAGCTCCTGGCGTCGTTGGACTGGCTGTTGGCACGCGAGGGCCGCGACCCAAGCGTGGAGAGTATCCGCGTA
GGACTCTCGGAATGGCCCGGTGGCGAATCGGCGGGGCGACGGAAATATCGGCTGTTCGATGAGCGAGCAATCCGTATTGG
ACTGAATCGGCTGACCGAACGAACTGGCGTGAGTACGTGCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References