218422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 7338..7866 Replicon plasmid pXMC5X702-13k
Accession NZ_CP084303
Organism Acinetobacter pseudolwoffii strain XMC5X702

Toxin (Protein)


Gene name relE Uniprot ID N8SCV7
Locus tag LDO52_RS16050 Protein ID WP_004733298.1
Coordinates 7338..7631 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1E8DZ10
Locus tag LDO52_RS16055 Protein ID WP_026438268.1
Coordinates 7621..7866 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO52_RS16020 (LDO52_16025) 4144..5100 + 957 WP_225554425.1 restriction endonuclease subunit S -
LDO52_RS16025 (LDO52_16030) 5185..5499 - 315 WP_004282216.1 BrnA antitoxin family protein -
LDO52_RS16030 (LDO52_16035) 5486..5773 - 288 WP_225554426.1 BrnT family toxin -
LDO52_RS16035 (LDO52_16040) 6104..6430 - 327 WP_005108845.1 hypothetical protein -
LDO52_RS16040 (LDO52_16045) 6420..6851 - 432 WP_225554428.1 hypothetical protein -
LDO52_RS16045 (LDO52_16050) 6958..7272 + 315 WP_005108843.1 hypothetical protein -
LDO52_RS16050 (LDO52_16055) 7338..7631 - 294 WP_004733298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO52_RS16055 (LDO52_16060) 7621..7866 - 246 WP_026438268.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDO52_RS16060 (LDO52_16065) 7961..8296 - 336 WP_055414483.1 hypothetical protein -
LDO52_RS16065 (LDO52_16070) 8418..8549 + 132 Protein_13 cysteine hydrolase -
LDO52_RS16070 (LDO52_16075) 8796..9086 - 291 WP_225554413.1 hypothetical protein -
LDO52_RS16075 (LDO52_16080) 9086..9727 - 642 WP_166172040.1 AAA family ATPase -
LDO52_RS16080 (LDO52_16085) 10768..11307 + 540 WP_225554415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13484 13484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-74)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11252.46 Da        Isoelectric Point: 10.4456

>T218422 WP_004733298.1 NZ_CP084303:c7631-7338 [Acinetobacter pseudolwoffii]
MTYKLLRHKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLKGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T218422 NZ_CP115944:c2976117-2975824 [Ralstonia syzygii R24]
GTGCCACGAGTAATCATCACCGAAGGCGCTGCTCAGGGATTGGAGCGCTGCCGGCGTTTTTTGGCTGGCAAGAGTCCAGA
GGCGACCCGGCGGGCCGGTCAGACGATCGCACGGCACCTTGCAACGCTGGAGACGACACCCACCATTGGGCGACCGTTTG
CCGAGCTGCCGGAGTGGCGCGAGTTGGTGATCGAGTTCGGTGACTCAGGCTATGTGGCACTTTATCGTCACGAGCCGGCG
GATGACGCCGTGTATGTCCTCGCCTTCCGACACCAAAAAGAGGCCGGATACTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9248.61 Da        Isoelectric Point: 4.2821

>AT218422 WP_026438268.1 NZ_CP084303:c7866-7621 [Acinetobacter pseudolwoffii]
MATVNFRVDEALKEKSYSILKEQGIAPTEFFTNILEYIATTGKLPVQKALLSEEDTELLAIVRKRVNDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT218422 NZ_CP115944:c2976377-2976105 [Ralstonia syzygii R24]
ATGGCAACGTCACTCAAGATAGACGACGAGCTGAAGGCGCGCGTGCAGCACTTGGCCAGCCTGCGGGATCGGTCACCGCA
CTGGATCATGCGTGAGGCGATCAAGCTGTATGTCGAGCGCGAGGAGGCCCGGGAGAGCTTCAAGCAGGAAGCCCTCGCGT
CTTGGACCGCCTATCAGGAAACCGGCCGGCATTTGACTGGACAGGAAGTGCGCACCTGGTTGGAAACCTGGGGCACGGAT
CATGAGACAGGGCTGCCTGAGTGCCACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8SCV7

Antitoxin

Source ID Structure
AlphaFold DB A0A1E8DZ10

References