Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 5185..5773 | Replicon | plasmid pXMC5X702-13k |
| Accession | NZ_CP084303 | ||
| Organism | Acinetobacter pseudolwoffii strain XMC5X702 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | - |
| Locus tag | LDO52_RS16030 | Protein ID | WP_225554426.1 |
| Coordinates | 5486..5773 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | N9DAY7 |
| Locus tag | LDO52_RS16025 | Protein ID | WP_004282216.1 |
| Coordinates | 5185..5499 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDO52_RS16005 (LDO52_16010) | 1383..1574 | + | 192 | WP_225554419.1 | hypothetical protein | - |
| LDO52_RS16010 (LDO52_16015) | 1593..1892 | - | 300 | WP_225554421.1 | hypothetical protein | - |
| LDO52_RS16015 (LDO52_16020) | 2187..4142 | + | 1956 | WP_225554423.1 | N-6 DNA methylase | - |
| LDO52_RS16020 (LDO52_16025) | 4144..5100 | + | 957 | WP_225554425.1 | restriction endonuclease subunit S | - |
| LDO52_RS16025 (LDO52_16030) | 5185..5499 | - | 315 | WP_004282216.1 | BrnA antitoxin family protein | Antitoxin |
| LDO52_RS16030 (LDO52_16035) | 5486..5773 | - | 288 | WP_225554426.1 | BrnT family toxin | Toxin |
| LDO52_RS16035 (LDO52_16040) | 6104..6430 | - | 327 | WP_005108845.1 | hypothetical protein | - |
| LDO52_RS16040 (LDO52_16045) | 6420..6851 | - | 432 | WP_225554428.1 | hypothetical protein | - |
| LDO52_RS16045 (LDO52_16050) | 6958..7272 | + | 315 | WP_005108843.1 | hypothetical protein | - |
| LDO52_RS16050 (LDO52_16055) | 7338..7631 | - | 294 | WP_004733298.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LDO52_RS16055 (LDO52_16060) | 7621..7866 | - | 246 | WP_026438268.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| LDO52_RS16060 (LDO52_16065) | 7961..8296 | - | 336 | WP_055414483.1 | hypothetical protein | - |
| LDO52_RS16065 (LDO52_16070) | 8418..8549 | + | 132 | Protein_13 | cysteine hydrolase | - |
| LDO52_RS16070 (LDO52_16075) | 8796..9086 | - | 291 | WP_225554413.1 | hypothetical protein | - |
| LDO52_RS16075 (LDO52_16080) | 9086..9727 | - | 642 | WP_166172040.1 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..13484 | 13484 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11323.68 Da Isoelectric Point: 5.2217
>T218421 WP_225554426.1 NZ_CP084303:c5773-5486 [Acinetobacter pseudolwoffii]
MEQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDYEIIRIIS
ARQVTKAERDKYEHG
MEQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDYEIIRIIS
ARQVTKAERDKYEHG
Download Length: 288 bp
>T218421 NZ_CP115944:1450681-1451034 [Ralstonia syzygii R24]
ATGCCAATGATAAGACCGCTGCGCTGGGTGGGTTCAGCCAAGAAAGACCTGAGCGTGATGCCAGACGACGTGCAGGACAC
CTTCGGCTACGCGCTGCACCTGGCGCAGGTTGGTGGCAAGCACAGCCAAGCCAAGCCACTCAAGGGTTACGGCGGGGCGG
GTGTGCTGGAAGTGGTGGAAGACCACCAGGGCAATACCTACCGTGCCGTGTACACGGTACGCTATGCGGGGGCGGTATAC
GTGCTGCATTGCTTCCAGAAGAAATCGACGCATGGGATCGCCACGCCCAGACCGGACTTGGACCTGATTGAGGCCCGCCT
GAAGGCGGTGATTGCCCTGGAAAAGGAGCGCTAG
ATGCCAATGATAAGACCGCTGCGCTGGGTGGGTTCAGCCAAGAAAGACCTGAGCGTGATGCCAGACGACGTGCAGGACAC
CTTCGGCTACGCGCTGCACCTGGCGCAGGTTGGTGGCAAGCACAGCCAAGCCAAGCCACTCAAGGGTTACGGCGGGGCGG
GTGTGCTGGAAGTGGTGGAAGACCACCAGGGCAATACCTACCGTGCCGTGTACACGGTACGCTATGCGGGGGCGGTATAC
GTGCTGCATTGCTTCCAGAAGAAATCGACGCATGGGATCGCCACGCCCAGACCGGACTTGGACCTGATTGAGGCCCGCCT
GAAGGCGGTGATTGCCCTGGAAAAGGAGCGCTAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 12253.88 Da Isoelectric Point: 7.2029
>AT218421 WP_004282216.1 NZ_CP084303:c5499-5185 [Acinetobacter pseudolwoffii]
MSMVRYSRKELNEKFSDKQDAEIERLLAKGTVPDDQLDLSDIPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSRKELNEKFSDKQDAEIERLLAKGTVPDDQLDLSDIPEITDWSNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT218421 NZ_CP115944:1451037-1451378 [Ralstonia syzygii R24]
ATGAACACGTTTGCAACGATTGACGATATCGTGATCGAAGAGGGCAGCACCAACCCCTATGCCGATCTGGGCCGGCCGGA
CGCCGACGAGATGCTGGTGAAAGCGGGGCTGGCGCACGAGATTGCACAGATCATTAAGAGTCGGCACCTGACGCAGCAGC
GAGCGGCCGAGTTACTGGGCATGCCGCAGCCGAAGCTATCGGAGCTGCTGCGCGGCAAGTTCCGGGGCATCAGCCAGGCC
AAGATGATCGAGTGCTTGAACCGCCTGGGCCGCGACGTGGACATCGTGGTCAAGAAAGCAGGCCGGCGCGCACTGGGCCA
TACGCACGTCGTCGTTGTGTGA
ATGAACACGTTTGCAACGATTGACGATATCGTGATCGAAGAGGGCAGCACCAACCCCTATGCCGATCTGGGCCGGCCGGA
CGCCGACGAGATGCTGGTGAAAGCGGGGCTGGCGCACGAGATTGCACAGATCATTAAGAGTCGGCACCTGACGCAGCAGC
GAGCGGCCGAGTTACTGGGCATGCCGCAGCCGAAGCTATCGGAGCTGCTGCGCGGCAAGTTCCGGGGCATCAGCCAGGCC
AAGATGATCGAGTGCTTGAACCGCCTGGGCCGCGACGTGGACATCGTGGTCAAGAAAGCAGGCCGGCGCGCACTGGGCCA
TACGCACGTCGTCGTTGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|