Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 21538..22126 Replicon plasmid pXMC5X702-195k
Accession NZ_CP084301
Organism Acinetobacter pseudolwoffii strain XMC5X702

Toxin (Protein)


Gene name relE Uniprot ID N9MLD7
Locus tag LDO52_RS14345 Protein ID WP_005175534.1
Coordinates 21830..22126 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2S4T219
Locus tag LDO52_RS14340 Protein ID WP_060875721.1
Coordinates 21538..21828 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO52_RS14300 (LDO52_14300) 16827..17312 - 486 WP_225554184.1 transposase -
LDO52_RS14305 (LDO52_14305) 17360..17665 - 306 WP_087547287.1 IS630 transposase-related protein -
LDO52_RS14310 (LDO52_14310) 17789..17950 + 162 Protein_13 IS6 family transposase -
LDO52_RS14315 (LDO52_14315) 17992..18294 - 303 WP_001140620.1 XRE family transcriptional regulator -
LDO52_RS14320 (LDO52_14320) 18287..18643 - 357 WP_004668307.1 type II toxin-antitoxin system RelE/ParE family toxin -
LDO52_RS14325 (LDO52_14325) 19330..19527 + 198 WP_100535484.1 hypothetical protein -
LDO52_RS14330 (LDO52_14330) 19530..20960 - 1431 WP_100535483.1 PLP-dependent aminotransferase family protein -
LDO52_RS14335 (LDO52_14335) 21054..21443 + 390 WP_225554361.1 hypothetical protein -
LDO52_RS14340 (LDO52_14340) 21538..21828 - 291 WP_060875721.1 putative addiction module antidote protein Antitoxin
LDO52_RS14345 (LDO52_14345) 21830..22126 - 297 WP_005175534.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO52_RS14350 (LDO52_14350) 22341..23114 - 774 WP_225554389.1 glucose 1-dehydrogenase -
LDO52_RS14355 (LDO52_14355) 23212..24414 - 1203 WP_225554362.1 alpha/beta fold hydrolase -
LDO52_RS14360 (LDO52_14360) 24516..25220 - 705 WP_086200040.1 IS6 family transposase -
LDO52_RS14365 (LDO52_14365) 25258..25476 + 219 WP_225554364.1 HNH endonuclease -
LDO52_RS14370 (LDO52_14370) 25581..25808 + 228 Protein_25 transposase domain-containing protein -
LDO52_RS14375 (LDO52_14375) 25840..26160 + 321 Protein_26 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..195429 195429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11568.25 Da        Isoelectric Point: 5.8801

>T218415 WP_005175534.1 NZ_CP084301:c22126-21830 [Acinetobacter pseudolwoffii]
MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS
TQQQDIDRAVKLSKTLED

Download         Length: 297 bp

>T218415 NZ_CP115941:c1767777-1767517 [Ralstonia syzygii]
CTGCGCGACAAGCGTGCCAAGGCGCGGATCGCCGCCCGGCTGGTCAGCGCATCGTTCGGGAATTTCGGCGACTGCAAGCC
GGTGGGTGAAGGCGTGAGCGAGATGCGGATCGATGTGGGCGCCGGGTATCGCGTCTACTACACGCGACAAGGTACTGTCG
TCTACATCCTGCTCACGGGCGGCAACAAGGCAACCCAAGCCCAGGACATCAAGCAAGCCATCCGGATGGCACGCGACCTG
AAGGAGTCAGGCCATGACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10519.17 Da        Isoelectric Point: 5.6088

>AT218415 WP_060875721.1 NZ_CP084301:c21828-21538 [Acinetobacter pseudolwoffii]
MVKVADLPSFDMAESLKTEEDIVMYLNMVLEDNDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRHDSAPRFDTI
NRVVNALGLKLTVQHA

Download         Length: 291 bp

>AT218415 NZ_CP115941:c1767524-1767237 [Ralstonia syzygii]
ATGACTGAAACCTACGCACCGTTTGACGCGGCGGCCTACCTCGATAGCGAAGAGACCATCGCCGAATTTCTGGCGGCCGC
GATGGAAGACCCGAATCCGGATGTCTTCCTGGCTGCCCTCGGTGCCGTTGCACGCGCCTGCGGCATTGCCAAGGTGGCTG
CGGACGCGGGCCTGGGGCGCGAAAGCCTGTACAAGGCCATCAGCCCCGGCGCGCACCCGCGCTACGAAACCATCCAGAAA
ATCATGCGCGCACTGGGCGTCAGGCTGAACGTGACGCCTGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9MLD7

Antitoxin

Source ID Structure
AlphaFold DB A0A2S4T219

References