Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 14631..15215 Replicon plasmid pLHC22-2-tetX-162k
Accession NZ_CP084298
Organism Acinetobacter baumannii strain LHC22-2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LDO71_RS18570 Protein ID WP_154320144.1
Coordinates 14913..15215 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LDO71_RS18565 Protein ID WP_000985610.1
Coordinates 14631..14912 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO71_RS18545 (LDO71_18550) 9970..11133 - 1164 WP_032073150.1 efflux RND transporter periplasmic adaptor subunit -
LDO71_RS18550 (LDO71_18555) 11560..12156 + 597 WP_074163998.1 LysE family transporter -
LDO71_RS18555 (LDO71_18560) 12184..13002 - 819 WP_032073151.1 AraC family transcriptional regulator -
LDO71_RS18560 (LDO71_18565) 13199..14524 + 1326 WP_001280601.1 ISNCY family transposase -
LDO71_RS18565 (LDO71_18570) 14631..14912 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
LDO71_RS18570 (LDO71_18575) 14913..15215 - 303 WP_154320144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO71_RS18575 (LDO71_18580) 15333..16658 - 1326 WP_001280601.1 ISNCY family transposase -
LDO71_RS18580 (LDO71_18585) 16952..17161 + 210 WP_004976362.1 hypothetical protein -
LDO71_RS18585 (LDO71_18590) 17411..18865 + 1455 WP_026438532.1 SulP family inorganic anion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 / floR / tet(M) / aac(3)-IVa / aph(4)-Ia / sul2 / tet(X6) / dfrA1 / ant(3'')-Ia / mph(E) / msr(E) / erm(B) - 1..162264 162264
- inside IScluster/Tn floR / tet(M) / aac(3)-IVa / aph(4)-Ia / sul2 / tet(X6) / dfrA1 / ant(3'')-Ia - 13187..53818 40631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11558.10 Da        Isoelectric Point: 4.6838

>T218412 WP_154320144.1 NZ_CP084298:c15215-14913 [Acinetobacter baumannii]
MYSIYTTEVFDDWFTKLKDLQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T218412 NZ_CP115936:2972680-2972937 [Streptomyces goshikiensis]
GTGAGGAGCGTTCACTTCGACCCCGCCGCCTGGGAGGACTTCCTGTTCTGGCTCTCCTCCGACCGCAAGACGGCCCGTCG
GATCACCCGCCTGATCGGCGAGATCCAGCGCGACCCGTTCACCGGGATCGGCAAGCCCGAGCCCCTGAAGGGCGAACTGA
CCGGTTACTGGTCCCGCCGGATCGACGACGAACACCGCCTCGTGTACCGGGCGGACGACAAGGAAGTGAAGGTGCTCAAG
GCCCGGTATCACTACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT218412 WP_000985610.1 NZ_CP084298:c14912-14631 [Acinetobacter baumannii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT218412 NZ_CP115936:2972408-2972683 [Streptomyces goshikiensis]
ATGTCGATAAGCGCCAGTGAAGCCAGGGCGACCCTGTTCCCCTTGATCGAACGCGTCAACACCGACCACGACCCGGTGCG
CATCACCTCCAAGAACGGCGACGCCGTCCTGATGTCCGCCGACGACTACGACTCCTGGCAGGAGACGGTCTACCTGCTGC
GCTCCCCCGCCAACGCCCAGAGGCTGATGGAGGCCGTCGCCCGCGATCGCGAGGGCGCGCCCGCGGTCACCAAGTCCATG
GAAGAGCTGAGGCGGTTGGCCGGAGGGGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References