Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1795847..1797483 Replicon chromosome
Accession NZ_CP084297
Organism Acinetobacter baumannii strain LHC22-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LDO71_RS08350 Protein ID WP_225546432.1
Coordinates 1795847..1797178 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LDO71_RS08355 Protein ID WP_001101310.1
Coordinates 1797175..1797483 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO71_RS08330 (LDO71_08330) 1792158..1793321 + 1164 WP_225546428.1 hypothetical protein -
LDO71_RS08335 (LDO71_08335) 1793449..1794420 + 972 WP_225546429.1 5'/3'-nucleotidase SurE -
LDO71_RS08340 (LDO71_08340) 1794432..1795076 + 645 WP_225546430.1 hypothetical protein -
LDO71_RS08345 (LDO71_08345) 1795111..1795551 - 441 WP_225546431.1 HD domain-containing protein -
LDO71_RS08350 (LDO71_08350) 1795847..1797178 + 1332 WP_225546432.1 HipA domain-containing protein Toxin
LDO71_RS08355 (LDO71_08355) 1797175..1797483 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
LDO71_RS08360 (LDO71_08360) 1798206..1798766 + 561 WP_225546433.1 TetR/AcrR family transcriptional regulator -
LDO71_RS08365 (LDO71_08365) 1798955..1800058 + 1104 WP_225546434.1 hypothetical protein -
LDO71_RS08370 (LDO71_08370) 1800127..1800621 + 495 WP_114172228.1 phage antirepressor KilAC domain-containing protein -
LDO71_RS08375 (LDO71_08375) 1800879..1801580 - 702 WP_225546435.1 hypothetical protein -
LDO71_RS08380 (LDO71_08380) 1801577..1802416 - 840 WP_000235266.1 PAAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51175.27 Da        Isoelectric Point: 4.9147

>T218411 WP_225546432.1 NZ_CP084297:1795847-1797178 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPDSTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T218411 NZ_CP115933:c127291-126809 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT218411 WP_001101310.1 NZ_CP084297:1797175-1797483 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT218411 NZ_CP115933:c127545-127279 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References