Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4088543..4089199 Replicon chromosome
Accession NZ_CP084296
Organism Providencia alcalifaciens strain LHC2-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LDO51_RS18925 Protein ID WP_132495542.1
Coordinates 4088543..4088728 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LDO51_RS18930 Protein ID WP_225575796.1
Coordinates 4088783..4089199 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO51_RS18905 (LDO51_18905) 4084459..4085547 - 1089 WP_225575793.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
LDO51_RS18910 (LDO51_18910) 4085550..4086410 - 861 WP_225575794.1 sulfate/thiosulfate ABC transporter permease CysW -
LDO51_RS18915 (LDO51_18915) 4086410..4087240 - 831 WP_036949525.1 sulfate/thiosulfate ABC transporter permease CysT -
LDO51_RS18920 (LDO51_18920) 4087240..4088262 - 1023 WP_225575795.1 sulfate ABC transporter substrate-binding protein -
LDO51_RS18925 (LDO51_18925) 4088543..4088728 + 186 WP_132495542.1 type II toxin-antitoxin system HicA family toxin Toxin
LDO51_RS18930 (LDO51_18930) 4088783..4089199 + 417 WP_225575796.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDO51_RS18935 (LDO51_18935) 4089250..4090146 - 897 WP_225575797.1 Dyp-type peroxidase -
LDO51_RS18940 (LDO51_18940) 4090383..4090967 - 585 WP_225575798.1 RpoE-regulated lipoprotein -
LDO51_RS18945 (LDO51_18945) 4091070..4091501 - 432 WP_225577314.1 GNAT family acetyltransferase -
LDO51_RS18950 (LDO51_18950) 4091638..4092561 + 924 WP_225575799.1 oxygen-dependent coproporphyrinogen oxidase -
LDO51_RS18955 (LDO51_18955) 4092711..4093841 + 1131 WP_225575800.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7012.22 Da        Isoelectric Point: 10.7918

>T218408 WP_132495542.1 NZ_CP084296:4088543-4088728 [Providencia alcalifaciens]
MKSSELINMLENNGWKLERVKGSHHQFSHPDFSIVITVPHPRKDLKIGTLNQILKAAKLKH

Download         Length: 186 bp

>T218408 NZ_CP115930:c4926449-4925532 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15591.35 Da        Isoelectric Point: 4.5082

>AT218408 WP_225575796.1 NZ_CP084296:4088783-4089199 [Providencia alcalifaciens]
MLYPAFIEIDHDGSASGWFPDIEGCTFAGNNIEDAYTDAKSALDAHFELLSEKGFEIPEPKSQQEHLSCAKDEYQNGLWL
FVDIDMDKYDGRAERINITLPHRLLHRIDTLVKANPEYGSRSGFIAAAARKELQKTDQ

Download         Length: 417 bp

>AT218408 NZ_CP115930:c4927213-4926455 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References