218407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2961742..2962286 Replicon chromosome
Accession NZ_CP084296
Organism Providencia alcalifaciens strain LHC2-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LDO51_RS13505 Protein ID WP_225574969.1
Coordinates 2961742..2962050 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LDO51_RS13510 Protein ID WP_225574970.1
Coordinates 2962050..2962286 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO51_RS13480 (LDO51_13480) 2956914..2958479 + 1566 WP_225574965.1 methyl-accepting chemotaxis protein -
LDO51_RS13485 (LDO51_13485) 2958621..2959460 + 840 WP_225574966.1 CheR family methyltransferase -
LDO51_RS13490 (LDO51_13490) 2959457..2960524 + 1068 WP_225574967.1 chemotaxis response regulator protein-glutamate methylesterase -
LDO51_RS13495 (LDO51_13495) 2960567..2960959 + 393 WP_225574968.1 chemotaxis response regulator CheY -
LDO51_RS13500 (LDO51_13500) 2960984..2961628 + 645 WP_132494647.1 protein phosphatase CheZ -
LDO51_RS13505 (LDO51_13505) 2961742..2962050 - 309 WP_225574969.1 CcdB family protein Toxin
LDO51_RS13510 (LDO51_13510) 2962050..2962286 - 237 WP_225574970.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LDO51_RS13515 (LDO51_13515) 2962430..2962570 - 141 Protein_2603 N-acetyltransferase -
LDO51_RS13520 (LDO51_13520) 2962829..2963176 - 348 WP_006657500.1 HNH nuclease YajD -
LDO51_RS13525 (LDO51_13525) 2963461..2964612 + 1152 WP_225574971.1 flagellar biosynthesis protein FlhB -
LDO51_RS13530 (LDO51_13530) 2964605..2966701 + 2097 WP_225574972.1 flagellar biosynthesis protein FlhA -
LDO51_RS13535 (LDO51_13535) 2966958..2967095 + 138 WP_225574973.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-76)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11665.70 Da        Isoelectric Point: 5.5703

>T218407 WP_225574969.1 NZ_CP084296:c2962050-2961742 [Providencia alcalifaciens]
MQYCVYQAKKELTNYPYLLDVQSDITDDLTTRLIIPLFDTRHLQAALPIRLNPIIDIEGQSFVLMTHLMSAISKSMLGKE
IICIEHQKDKIKSAIDLLVDGF

Download         Length: 309 bp

>T218407 NZ_CP115930:c4767327-4767043 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8927.24 Da        Isoelectric Point: 6.3221

>AT218407 WP_225574970.1 NZ_CP084296:c2962286-2962050 [Providencia alcalifaciens]
MTVTNKMKKTVSVTVSPELYEQARKANLNFSLVLSNALLAELKKLEALKWKADNQDGFQELNRISEEYGIFSEEYKAL

Download         Length: 237 bp

>AT218407 NZ_CP115930:c4767559-4767317 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References