Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 1681983..1682554 Replicon chromosome
Accession NZ_CP084296
Organism Providencia alcalifaciens strain LHC2-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LDO51_RS07755 Protein ID WP_225576992.1
Coordinates 1681983..1682303 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LDO51_RS07760 Protein ID WP_225576993.1
Coordinates 1682303..1682554 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO51_RS07745 (LDO51_07745) 1680423..1681043 - 621 WP_132496945.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
LDO51_RS07750 (LDO51_07750) 1681311..1681883 + 573 WP_225576991.1 peptidylprolyl isomerase A -
LDO51_RS07755 (LDO51_07755) 1681983..1682303 - 321 WP_225576992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO51_RS07760 (LDO51_07760) 1682303..1682554 - 252 WP_225576993.1 hypothetical protein Antitoxin
LDO51_RS07765 (LDO51_07765) 1682935..1683510 + 576 WP_225576994.1 aminodeoxychorismate synthase component II -
LDO51_RS07770 (LDO51_07770) 1683642..1684856 + 1215 WP_225576995.1 aspartate aminotransferase family protein -
LDO51_RS07775 (LDO51_07775) 1684911..1686563 - 1653 WP_225576996.1 hypothetical protein -
LDO51_RS07780 (LDO51_07780) 1686774..1687406 - 633 WP_006813718.1 cAMP-activated global transcriptional regulator CRP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12443.40 Da        Isoelectric Point: 10.4375

>T218404 WP_225576992.1 NZ_CP084296:c1682303-1681983 [Providencia alcalifaciens]
MNKNFSVRLTFKPLAKKEWNSLNSSIKDKFKKILRKRTESYELLTAPSNRLSLQYNCYKIKLKKDGYRLAYTVKSDDVGN
VQVTVAVVAVDRHDEIYNELNKRLKD

Download         Length: 321 bp

>T218404 NZ_CP115930:c2630846-2629524 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9337.76 Da        Isoelectric Point: 4.5680

>AT218404 WP_225576993.1 NZ_CP084296:c1682554-1682303 [Providencia alcalifaciens]
MYTKTLLAKKTSSISEFKKNPSAAMNESNGEPVAILSHNKAIFYCVPTDLFELMVEKLGDQLLLEKTIARMNDAEIEVSW
DDL

Download         Length: 252 bp

>AT218404 NZ_CP115930:c2631112-2630846 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References