Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 105553..106210 Replicon chromosome
Accession NZ_CP084296
Organism Providencia alcalifaciens strain LHC2-1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LDO51_RS00460 Protein ID WP_225575947.1
Coordinates 105553..105963 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag LDO51_RS00465 Protein ID WP_036951240.1
Coordinates 105944..106210 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO51_RS00440 (LDO51_00440) 101528..103261 - 1734 WP_225575944.1 single-stranded-DNA-specific exonuclease RecJ -
LDO51_RS00445 (LDO51_00445) 103270..103971 - 702 WP_225575945.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDO51_RS00450 (LDO51_00450) 103989..104891 - 903 WP_225575946.1 site-specific tyrosine recombinase XerD -
LDO51_RS00455 (LDO51_00455) 105009..105527 + 519 WP_154602566.1 flavodoxin FldB -
LDO51_RS00460 (LDO51_00460) 105553..105963 - 411 WP_225575947.1 protein YgfX Toxin
LDO51_RS00465 (LDO51_00465) 105944..106210 - 267 WP_036951240.1 FAD assembly factor SdhE Antitoxin
LDO51_RS00470 (LDO51_00470) 106502..107488 + 987 WP_225575948.1 tRNA-modifying protein YgfZ -
LDO51_RS00475 (LDO51_00475) 107500..108120 + 621 WP_036951137.1 HD domain-containing protein -
LDO51_RS00480 (LDO51_00480) 108191..111067 - 2877 WP_225575949.1 aminomethyl-transferring glycine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15469.40 Da        Isoelectric Point: 10.7520

>T218401 WP_225575947.1 NZ_CP084296:c105963-105553 [Providencia alcalifaciens]
VVLWKSNLSISWKTQLFSTCLHGVTGIILLVAPWAPGNSMIWLPLLVVLVASWAKSQKNISKVKGVAVLVNGNKLQWKKN
EWEIIKAPWCSRFGILLTLNALQGKPQKIRLWIAKDSISEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T218401 NZ_CP115930:737836-738321 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10720.26 Da        Isoelectric Point: 4.9148

>AT218401 WP_036951240.1 NZ_CP084296:c106210-105944 [Providencia alcalifaciens]
IDINNKARIHWACRRGMRELDISIMPFFEYEYDELTDHDKRVFVRLLECPDPDLFNWLMNHGRPEDEELFSMIKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT218401 NZ_CP115930:737546-737839 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References