Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 4310291..4310810 Replicon chromosome
Accession NZ_CP084290
Organism Citrobacter werkmanii strain LHC5-1

Toxin (Protein)


Gene name relE Uniprot ID A0A2Z3WY74
Locus tag LD024_RS20420 Protein ID WP_038636706.1
Coordinates 4310291..4310572 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2Z3X2E3
Locus tag LD024_RS20425 Protein ID WP_038636704.1
Coordinates 4310562..4310810 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD024_RS20405 (4307293) 4307293..4307757 + 465 WP_069324767.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LD024_RS20410 (4307779) 4307779..4308300 - 522 WP_227410014.1 toxin-antitoxin system YwqK family antitoxin -
LD024_RS20415 (4308300) 4308300..4310264 - 1965 WP_227410015.1 type VI secretion system tip protein TssI/VgrG -
LD024_RS20420 (4310291) 4310291..4310572 - 282 WP_038636706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LD024_RS20425 (4310562) 4310562..4310810 - 249 WP_038636704.1 plasmid stabilization protein Antitoxin
LD024_RS20430 (4310958) 4310958..4311593 - 636 WP_137351307.1 hypothetical protein -
LD024_RS20435 (4311619) 4311619..4314141 - 2523 WP_227410016.1 type VI secretion system ATPase TssH -
LD024_RS20440 (4314041) 4314041..4315075 - 1035 WP_227410017.1 type VI secretion system baseplate subunit TssG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.76 Da        Isoelectric Point: 10.4466

>T218397 WP_038636706.1 NZ_CP084290:c4310572-4310291 [Citrobacter werkmanii]
MTYSLEFLDIALKEWRKLSPTLREQFKKKLAERLENPHVPAARLSGKLHRYKIKLRSAGYRLVYQVEDEQVVVLVIAVGR
RDGDEVYHQANRR

Download         Length: 282 bp

>T218397 NZ_CP115926:284547-284966 [Agrobacterium fabacearum]
ATGATCTTGCTTGACACCAACGTCATATCCGAACCTTGGAAACCGGTTCCGGACGAGGCGGTGATTGCCTGGTTGGACGC
GCAAGCTGTCGAAACGCTGTTCATCTCCGCAATAACGATTGCGGAACTTCGCTTCGGAATTGCTGCTATGCCTTCAGGCA
GACGGCAAACTATCCTCCGCGACCGTCTCGAGGGCGAGGTGCTGCCACACTTTTCCGGCCGCATCCTGTCCTTCGATCTG
ACTACTTCTCAGTTCTACTCTGAACTGATGGCACGCGCTCGAGCGACTAGGAAAGCAATCGGCACGGCCGATGGCTACAT
TGCAGCCACAGCGGCAGCAAATGGCCTCACGATCTCAACTCGCGATACAAGCCCTTTCGAGGCTGCCGGGGTGAAAGTGA
TCAACCCCTGGTCCAGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8987.23 Da        Isoelectric Point: 4.5338

>AT218397 WP_038636704.1 NZ_CP084290:c4310810-4310562 [Citrobacter werkmanii]
MPFHILTKTAASITDLKRNPMGTVNAGEGEAVAILNRNEPAFYCVPPAVYAYLLELAEDAELNRIADEREGGKRIQVSLN
DL

Download         Length: 249 bp

>AT218397 NZ_CP115926:284296-284550 [Agrobacterium fabacearum]
ATGCCGGCAGTCACCATTCGTAACCTTTCTGAAGAAACACATCGCGCTCTGAGGGTGCGAGCGGCTCATCATGGCCGGAG
CACGGAGGCCGAGATTCGTGCCATTATTGAAGCGGCCGTTCGTCCTCCGGAACGTATTCAGCTCGGTTCCTTGCTCGCGG
CCATTGGTCGCGACGCCGAGCTTTCCAACAGCGACGTTGAAGCTCTTCAGAAAAGTCGCGACAAGACACCTGCTAAGCCG
ATGACCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3WY74

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3X2E3

References