Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2484285..2484924 Replicon chromosome
Accession NZ_CP084290
Organism Citrobacter werkmanii strain LHC5-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LD024_RS11755 Protein ID WP_085048165.1
Coordinates 2484285..2484461 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LD024_RS11760 Protein ID WP_087856629.1
Coordinates 2484508..2484924 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD024_RS11735 (2481062) 2481062..2481292 - 231 WP_038640744.1 DUF2554 family protein -
LD024_RS11740 (2481482) 2481482..2481607 - 126 WP_064507023.1 DUF2474 domain-containing protein -
LD024_RS11745 (2481607) 2481607..2482617 - 1011 WP_087856574.1 cytochrome d ubiquinol oxidase subunit II -
LD024_RS11750 (2482617) 2482617..2484020 - 1404 WP_038640740.1 cytochrome ubiquinol oxidase subunit I -
LD024_RS11755 (2484285) 2484285..2484461 + 177 WP_085048165.1 type II toxin-antitoxin system HicA family toxin Toxin
LD024_RS11760 (2484508) 2484508..2484924 + 417 WP_087856629.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LD024_RS11765 (2485017) 2485017..2486426 + 1410 WP_069324935.1 PLP-dependent aminotransferase family protein -
LD024_RS11770 (2486756) 2486756..2487901 + 1146 WP_069324934.1 ABC transporter substrate-binding protein -
LD024_RS11775 (2487918) 2487918..2488934 + 1017 WP_204525140.1 ABC transporter ATP-binding protein -
LD024_RS11780 (2488935) 2488935..2489879 + 945 WP_069324933.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6783.83 Da        Isoelectric Point: 11.6208

>T218395 WP_085048165.1 NZ_CP084290:2484285-2484461 [Citrobacter werkmanii]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLQ

Download         Length: 177 bp

>T218395 NZ_CP115926:c152435-152052 [Agrobacterium fabacearum]
GTGATCCTGGTAGACACCTCGATCTGGATAGATCATTTTCGATACGATGACTCAGAACTACGAAAAATCATCAATGATGA
CCAGCTGCTCTGCCACCCTTTCGTTGTAGGCGAATTGGCGCTCGGCAGCTTAAGAGAGCGGGCTGCAGTTTTAGAGTTCC
TAACAGCTCAACGCGAGGCGCTAATCGCGACCCATGCAGAAGTAATGACGGTCATTGATCGTCATTCGATATTCAGCATG
GGGATTGGTTACACAGATGCGCATTTACTTACTTCAACGTTGCTCGACCGGCGATCAAGCTTATGGACAAGAGATAAGCG
CCTAGCGGCCGCAGCGCAAAAAGTTGGTGCGGCACTTTACCCGCACGCGCAAGCCTCTCATTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.35 Da        Isoelectric Point: 4.5468

>AT218395 WP_087856629.1 NZ_CP084290:2484508-2484924 [Citrobacter werkmanii]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT218395 NZ_CP115926:c152632-152432 [Agrobacterium fabacearum]
ATGCGATCAACCATAAATATCGACGACAATCTTATGGAACGGGCCAAGTCCCTCACGGGCACCAAAGAAACAGCAGCTCT
CGTGCGGCAAGCGCTGGAGACACTTGTGCGTGTGGAATCCGGCAAACGGCTGATCGCGCTTGGCGGCTCTATGCCTGAGG
CTGAAGCGTCGCCGCGCCGACGGAGCGACGTGGCAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References