Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 908761..909415 Replicon chromosome
Accession NZ_CP084290
Organism Citrobacter werkmanii strain LHC5-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag LD024_RS04460 Protein ID WP_038633481.1
Coordinates 909008..909415 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag LD024_RS04455 Protein ID WP_016154349.1
Coordinates 908761..909027 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD024_RS04430 (903963) 903963..905396 - 1434 WP_038633498.1 6-phospho-beta-glucosidase BglA -
LD024_RS04435 (905517) 905517..906245 - 729 WP_061382417.1 MurR/RpiR family transcriptional regulator -
LD024_RS04440 (906298) 906298..906609 + 312 WP_085048763.1 N(4)-acetylcytidine aminohydrolase -
LD024_RS04445 (906773) 906773..907432 + 660 WP_038633489.1 hemolysin III family protein -
LD024_RS04450 (907524) 907524..908504 - 981 WP_069324821.1 tRNA-modifying protein YgfZ -
LD024_RS04455 (908761) 908761..909027 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
LD024_RS04460 (909008) 909008..909415 + 408 WP_038633481.1 protein YgfX Toxin
LD024_RS04465 (909516) 909516..910037 - 522 WP_038633478.1 flavodoxin FldB -
LD024_RS04470 (910151) 910151..911047 + 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
LD024_RS04475 (911071) 911071..911784 + 714 WP_061382414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LD024_RS04480 (911790) 911790..913523 + 1734 WP_085048766.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T218386 WP_038633481.1 NZ_CP084290:909008-909415 [Citrobacter werkmanii]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T218386 NZ_CP115911:427471-427605 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT218386 WP_016154349.1 NZ_CP084290:908761-909027 [Citrobacter werkmanii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218386 NZ_CP115911:427255-427407 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References