Detailed information of TA system TA218382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 399960..400498
• Replicon: plasmid p3
• Accession: NZ_CP084287
• Organism: Caballeronia zhejiangensis strain A33_M4_a

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LDZ23_RS31570
• Protein ID: WP_244808356.1
• Coordinates: 400199..400498 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LDZ23_RS31565
• Protein ID: WP_244808868.1
• Coordinates: 399960..400202 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDZ23_RS31545	395198..396064	-	867	WP_244808354.1	hypothetical protein	-
LDZ23_RS31550	396917..397699	-	783	Protein_396	IS256 family transposase	-
LDZ23_RS31555	397758..399299	-	1542	WP_008352264.1	IS3 family transposase	-
LDZ23_RS31560	399528..399791	+	264	WP_244808355.1	site-specific integrase	-
LDZ23_RS31565	399960..400202	+	243	WP_244808868.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LDZ23_RS31570	400199..400498	+	300	WP_244808356.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDZ23_RS31575	400906..402111	-	1206	WP_244808357.1	sugar transporter	-
LDZ23_RS31580	402264..404774	-	2511	WP_244808358.1	DNA ligase D	-
LDZ23_RS31585	404856..405032	-	177	WP_244808359.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	cheW / hsiB1/vipA / hsiC1/vipB / clpV1	1..666467	666467

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11355.86 Da
• Isoelectric Point: 6.1200

>T218382 WP_244808356.1 NZ_CP084287:400199-400498 [Caballeronia zhejiangensis]
MKEFVLSPAAELDLDDVWDYSAEHWGLNQAERYIRMIQDTIVGLAHGTQLSQGASHIRAGYRRALVGSHVLFFKETDTLI
DVIRILHQRMDPSQHLCDH

Nucleotide

• Length: 300 bp

>T218382 NZ_CP115904:c974079-973660 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9070.22 Da
• Isoelectric Point: 10.2633

>AT218382 WP_244808868.1 NZ_CP084287:399960-400202 [Caballeronia zhejiangensis]
MAKNTSVSLGEHFADFVEDRVRVGRYNTASDVVRAGLRLLEEQEAKLDTLRAELEKGERSGPSRPFNFDAFLARKRKSTK

Nucleotide

• Length: 243 bp

>AT218382 NZ_CP115904:c974315-974079 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA