Detailed information of TA system TA218381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 402880..404597
• Replicon: chromosome
• Accession: NZ_CP084286
• Organism: Caballeronia zhejiangensis strain A33_M4_a

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LDZ23_RS28040
• Protein ID: WP_008346001.1
• Coordinates: 402880..403740 (+)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A656QVP8
• Locus tag: LDZ23_RS28045
• Protein ID: WP_008346003.1
• Coordinates: 403737..404597 (+)
• Length: 287 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDZ23_RS28010	398362..399435	-	1074	WP_244808269.1	porin	-
LDZ23_RS28015	399863..400180	+	318	WP_008345991.1	non-heme iron oxygenase ferredoxin subunit	-
LDZ23_RS28020	400182..400490	+	309	WP_008345993.1	hypothetical protein	-
LDZ23_RS28025	400508..401566	+	1059	WP_008345995.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
LDZ23_RS28030	401559..402311	+	753	WP_008345996.1	SDR family oxidoreductase	-
LDZ23_RS28035	402345..402872	+	528	WP_244808270.1	cupin domain-containing protein	-
LDZ23_RS28040	402880..403740	+	861	WP_008346001.1	alpha/beta hydrolase	Toxin
LDZ23_RS28045	403737..404597	+	861	WP_008346003.1	IclR family transcriptional regulator	Antitoxin
LDZ23_RS28050	404594..405409	+	816	WP_244808271.1	SDR family oxidoreductase	-
LDZ23_RS28055	405402..407069	+	1668	WP_008346007.1	thiamine pyrophosphate-binding protein	-
LDZ23_RS28060	407062..407886	+	825	WP_008346008.1	aspartate dehydrogenase	-
LDZ23_RS28065	407901..409391	+	1491	WP_008346009.1	aldehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (36-265)

Antitoxin

• Transcription regulator IclR, N-terminal (21-69)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 30613.79 Da
• Isoelectric Point: 6.8735

>T218381 WP_008346001.1 NZ_CP084286:402880-403740 [Caballeronia zhejiangensis]
MNIQTLACFPDTHIETAHGITGYREAGAMHRRALPVVLLHGIGSGAASWVRQLDALGAKRRVIAWDAPGYGESSCIRNDS
PLALDYGQALRAWLDALDIDRCVIVGHSLGAIIAGSFAVHTPQRVAGLLLISPAAGYGAASKEVRESKRDARLKMLNELG
PQGLARERSANMLSHYADDEAREWVRWNMARIVPAGYAQATHLLANADLAADIARFHGRIAVAVGADDAITPPDACERIA
QAARVNLQVMPRAGHAGYVESPAAYTALIDAFCESIESHTKDGVPQ

Nucleotide

• Length: 861 bp

>T218381 NZ_CP115904:c949319-948900 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 287 a.a.
• Molecular weight: 31435.86 Da
• Isoelectric Point: 6.2561

>AT218381 WP_008346003.1 NZ_CP084286:403737-404597 [Caballeronia zhejiangensis]
MTSLATEEADKGEPTYIVPGLERGLKILTEFSPREPVLGAPELSRRLGIPRTTVFRLLQTLESLGFLERADKDRNYRLGV
AVLRLGFEYLSSLELTDLGLPIIEALRDATGLTSHILIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAHATTHGHVLM
GDLSLDELRALYPEAHLERFTTSTPETVEELFERVKEDAERGYATSQSSFERGISVVTAPVRNDTGRIVAVITTTIPRPE
IDAALLDSGLVDKVREAADALSMRLNYRPGARASASNRYMKSLGLQ

Nucleotide

• Length: 861 bp

>AT218381 NZ_CP115904:c949555-949319 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A656QVP8