Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1027796..1028373 Replicon chromosome
Accession NZ_CP084284
Organism Caballeronia zhejiangensis strain A33_M4_a

Toxin (Protein)


Gene name vapC Uniprot ID A0A656QMC5
Locus tag LDZ23_RS19315 Protein ID WP_008352955.1
Coordinates 1027796..1028161 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A656QIR1
Locus tag LDZ23_RS19320 Protein ID WP_008352954.1
Coordinates 1028155..1028373 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ23_RS19300 1023036..1024961 + 1926 WP_008352959.1 zinc ribbon domain-containing protein -
LDZ23_RS19305 1025173..1026312 + 1140 WP_008352958.1 TAXI family TRAP transporter solute-binding subunit -
LDZ23_RS19310 1026323..1027774 - 1452 WP_008352956.1 PLP-dependent aminotransferase family protein -
LDZ23_RS19315 1027796..1028161 - 366 WP_008352955.1 type II toxin-antitoxin system VapC family toxin Toxin
LDZ23_RS19320 1028155..1028373 - 219 WP_008352954.1 ribbon-helix-helix protein, CopG family Antitoxin
LDZ23_RS19325 1028421..1028684 - 264 WP_008352953.1 helix-turn-helix domain-containing protein -
LDZ23_RS19330 1028681..1030111 - 1431 WP_244808154.1 PLP-dependent aminotransferase family protein -
LDZ23_RS19335 1030263..1032578 + 2316 WP_008352951.1 FdhF/YdeP family oxidoreductase -
LDZ23_RS19340 1032568..1032963 + 396 WP_152563208.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13513.62 Da        Isoelectric Point: 4.8779

>T218380 WP_008352955.1 NZ_CP084284:c1028161-1027796 [Caballeronia zhejiangensis]
MVRALFDTNILIDYLLGIDAARKEIERYEERSISIITLMEVLEGAKPDSEASLRAWLSTFDLVPLDSAVANLAIGIRRKS
RIKLPDAIVWASAQSVNALLVSRNSKDFPPDDPGVRMPYQL

Download         Length: 366 bp

>T218380 NZ_CP084284:c1028161-1027796 [Caballeronia zhejiangensis]
ATGGTAAGAGCGCTTTTCGACACGAACATCCTGATCGATTACCTGTTGGGAATCGATGCGGCACGCAAGGAGATCGAGCG
TTACGAAGAGCGGTCGATCAGCATCATCACGCTCATGGAAGTTCTAGAGGGCGCCAAACCCGACAGTGAAGCGTCGCTGC
GCGCCTGGCTGTCCACCTTCGATCTCGTGCCGCTCGATTCGGCCGTCGCGAACCTCGCAATCGGAATTCGCAGGAAATCG
CGCATCAAGTTGCCGGATGCGATCGTGTGGGCGTCGGCGCAATCGGTGAATGCGCTGCTCGTTTCGCGCAACTCGAAGGA
CTTCCCGCCCGACGATCCGGGCGTGCGGATGCCCTATCAACTGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8383.45 Da        Isoelectric Point: 4.6017

>AT218380 WP_008352954.1 NZ_CP084284:c1028373-1028155 [Caballeronia zhejiangensis]
MGRILIDLPDEQIDELAAIGEEQQRPRAAVIRDAISAYVASNKRRSAVDVFGLWQERKIDGLQYQRELREEW

Download         Length: 219 bp

>AT218380 NZ_CP084284:c1028373-1028155 [Caballeronia zhejiangensis]
ATGGGAAGGATCTTGATCGATTTGCCCGACGAACAGATAGACGAACTCGCCGCGATCGGCGAAGAGCAGCAGCGCCCGCG
AGCCGCGGTCATTCGGGACGCGATCAGCGCGTACGTCGCGAGCAACAAGCGCCGTTCTGCCGTCGATGTGTTCGGCTTAT
GGCAAGAGCGAAAGATCGATGGATTGCAGTATCAGCGGGAGCTGCGCGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656QMC5

Antitoxin

Source ID Structure
AlphaFold DB A0A656QIR1

References