Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 800394..801009 Replicon chromosome
Accession NZ_CP084283
Organism Caballeronia zhejiangensis strain A33_M4_a

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LDZ23_RS03755 Protein ID WP_075644177.1
Coordinates 800394..800594 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LDZ23_RS03760 Protein ID WP_033536674.1
Coordinates 800608..801009 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ23_RS03745 797089..798852 + 1764 WP_008350803.1 ABC transporter permease subunit -
LDZ23_RS03750 798865..800220 + 1356 WP_033536675.1 nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein -
LDZ23_RS03755 800394..800594 + 201 WP_075644177.1 type II toxin-antitoxin system HicA family toxin Toxin
LDZ23_RS03760 800608..801009 + 402 WP_033536674.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDZ23_RS03765 801073..801597 - 525 WP_244807820.1 hypothetical protein -
LDZ23_RS03770 801594..802148 - 555 WP_175981819.1 hypothetical protein -
LDZ23_RS03775 802443..803510 - 1068 WP_008350797.1 sigma-54 dependent transcriptional regulator -
LDZ23_RS03780 804100..804429 + 330 WP_008350796.1 hypothetical protein -
LDZ23_RS03785 804478..804795 + 318 WP_008350795.1 DUF883 family protein -
LDZ23_RS03790 804867..805100 + 234 WP_008350794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7548.79 Da        Isoelectric Point: 11.7877

>T218379 WP_075644177.1 NZ_CP084283:800394-800594 [Caballeronia zhejiangensis]
MDSSRLIRMLLDDGWHLDRIVGSHHHFKRRGNMSLVTVPHPRKDLSIGTVRSVLKTAGLLNRLYSS

Download         Length: 201 bp

>T218379 NZ_CP115896:c154953-153646 [Kalamiella piersonii]
ATGGATCAGCTCAACGCCTGGATGAACGGCGAACGCGTCGGCACGCTGACGCGCCAGAAAAATGGCGCGCATATCTTTCA
GTATGAGCCAGGCTGGCTGAGCAATCCGCTGGCGAGGCCGCTGTCGCTCTCGCTGCCGCTGCAGTACCCCGCTATCGCCT
CCGCCAGCGTCATCAACTTCTTCGATAACCTGCTGCCTGATAATCCTCGCGTCAGAGAGCGCATTCTTAACCGTTATCGG
GCGAAGTCAATGCAGCCGTTCGATCTGCTGCGGGAAGTAGGCCGCGACAGCGTCGGCGCGGTGATGCTGCTGCCCGTTGA
GGCCGCCGCGCCCGATCTCTCTGTACGTTATGAACCGCTCGACGCCGCGCGGCTGGAAAAAATACTTTCGGCGTACCAGA
GCGATATTCCGCTGGGGATGATCCCGGAAGAGCGTGACTTCCGCATTTCCGTCGCGGGCGCGCAGGAGAAAACCGCGCTG
CTGAAAACCCCTCAGGGCTGGGCCGTCCCTCAGGGGCCGACGCCCACGTCGCATATCATTAAGCTGCCGATCGGCGAAAT
TAAGCAGCCTTTCGCGACGCTCGATATGTGCGACAGCGTGGAAAACGAATATGTCTGCCTGGCGCTGGCGCGCGAGCTGG
GTTTTCGCGTGCCTGACGCCGCCATTATCACGGCCGGCAAGCTGCGCGCGCTGGCGGTAGAGCGATTTGACCGGCGCTGG
AGCGCTGACGGCGTCCGGCTGCTGCGCCTGCCGCAGGAGGATATTTGCCAGAGCCTCGGCCTCGCCTCCGCGACAAAATA
TGAATCTGACGGCGGGCCGGGCATTGCGGCGATCATGTCGCTGCTGATGGGCTCCAGCAATGCGCTGGAGGATCGCGACG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGCTGCTCGGCGCGACCGACGGGCATGCGAAGAACTTTTCGCTCTATATCGAG
CGTGGTGGAAGCTACCGGTTGACGCCGTTCTACGACATTCTTTCCGCTTATCCGGTACTGGGCGGCACCGGCCTCAATAT
TCGCGAACTGAAGCTGGCGATGGGACTCACCGCGTCGAAGGGCAAGAAAGTGGAAATCGATAAAATCTTTCCGCGCCATT
TCCTCGCCACGGCGGCAAGCGTCCGCTTCTCCACCGAACGGATGGCGCAGATCCTCGCTTTCTTCGCGGAGGCGTTTCCG
GCCGCCGTGGCGCGCGTCAGGGAGCAACTGCCCGCCGATATCCCGCCCGCAATTGCCGAGGCTATTTTCAGTAACGCGCT
GAAAATGGCGGAGCGGCTTAGCCGGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14622.59 Da        Isoelectric Point: 4.3472

>AT218379 WP_033536674.1 NZ_CP084283:800608-801009 [Caballeronia zhejiangensis]
VEFPVAIHKDPDSCYGVTVPDIPGVFSAGETVDEAIKNTKEAIYSHVSILIEDGLDVSLVPSPIEDLMPNPDFATAIWAY
VEVDLSKLDSRPERINISLPRFVLRKIDSYVEARHETRSGFLARVALEAIANG

Download         Length: 402 bp

>AT218379 NZ_CP115896:c155189-154953 [Kalamiella piersonii]
ATGATCTACAGCCCACAACAGCTGGCCCATCTGATCAGGCTTGAACGGCAGAAGCGCGGCTGGACGCAGAGCGACCTGGC
GCGCCGGGTCGGCATCAAACAGGCCACCGTGTCGAACTTTGAAAATAATCCTGACAAGACTACGCTAACCACGCTGTTTA
AGATCCTGCAGTCGCTGGAGCAGGAGCTGGTAATTCAGAGTAAATCGACGCAGAGCGGCAAGGAGCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References