Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 153407..153872 Replicon chromosome
Accession NZ_CP084283
Organism Caballeronia zhejiangensis strain A33_M4_a

Toxin (Protein)


Gene name relE Uniprot ID A0A656QRX2
Locus tag LDZ23_RS00745 Protein ID WP_034470469.1
Coordinates 153407..153691 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A656QUP0
Locus tag LDZ23_RS00750 Protein ID WP_008351825.1
Coordinates 153681..153872 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ23_RS00715 148477..149478 + 1002 WP_144403733.1 MerR family transcriptional regulator -
LDZ23_RS00720 149874..150749 + 876 WP_033536551.1 acyl-ACP desaturase -
LDZ23_RS00725 150869..151351 + 483 WP_008351834.1 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase -
LDZ23_RS00730 151367..151606 - 240 WP_008351832.1 hypothetical protein -
LDZ23_RS00735 151641..152462 - 822 WP_008351830.1 type III pantothenate kinase -
LDZ23_RS00740 152459..153355 - 897 WP_008351828.1 biotin--[acetyl-CoA-carboxylase] ligase -
LDZ23_RS00745 153407..153691 - 285 WP_034470469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDZ23_RS00750 153681..153872 - 192 WP_008351825.1 hypothetical protein Antitoxin
LDZ23_RS00755 154055..155182 + 1128 WP_008351824.1 ABC transporter permease -
LDZ23_RS00760 155188..156066 + 879 WP_008351823.1 ATP-binding cassette domain-containing protein -
LDZ23_RS00765 156097..157056 + 960 WP_008351821.1 MlaD family protein -
LDZ23_RS00770 157070..157696 + 627 WP_008351820.1 ABC-type transport auxiliary lipoprotein family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11357.92 Da        Isoelectric Point: 10.1595

>T218378 WP_034470469.1 NZ_CP084283:c153691-153407 [Caballeronia zhejiangensis]
MLVDWRPRARRQLREIYEYIEERDPQAADNLLSMNREAVRTLADVPYIYRHGRVSNTREMVVHPNYLVVYRATDRVTVLD
SLHARRRYPSDKTR

Download         Length: 285 bp

>T218378 NZ_CP115895:2900382-2900600 [Kalamiella piersonii]
ATGAACGATAAAACTCTGACTAAAACTGATTATTTGATGCGGCTGAGACGTTGCCGCTCGATCGATACGCTTGAACGCGT
GATTGAAAAGAATAAGTATGAATTATCCGATGATGAACTGGCGGTATTCTACTCTGCCGCCGATCATCGTCTGGCTGAAC
TGACGATGAATAAGCTTTACGACAAAGTCCCTGGCTCAGTATGGAAGTTCGTGCGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7118.96 Da        Isoelectric Point: 4.0941

>AT218378 WP_008351825.1 NZ_CP084283:c153872-153681 [Caballeronia zhejiangensis]
MDKRLDPLISELDSLEEAELYDAWFRAEVEASLADPEPSIPNDQVFAEMDALVAAKRKARNAR

Download         Length: 192 bp

>AT218378 NZ_CP115895:2899981-2900358 [Kalamiella piersonii]
ATGGACGAGTACTCACCGAAACGGCATGATATTGCCCAGCTTAAATTCCTGTGTGAGAACCTGTTTGATGAAAGTATGGC
GACGCTAACCGACAGCCATCACGGCTGGGTTAACGACCCGACTTCAGAGAACAATTTACAGCTTAATGATTTGATTGAGC
ACATTGCTTCTTTCACGATGAATTACAAAATAAAGCATGCTGAAGATGAAGATCTGATAACGCAAATCGACGACTATCTT
GACGATACCTTTATGTTATTCACTAATTACGGTATCAATGCGCAAGATCTGAATCGGTGGCAGCGTTCCGCCCGGCGCTT
ATTTAATCTTTTTAGCGAAGAGTGCGCTTACCTTCAGCAACCCAGCCACTCCATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656QRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A656QUP0

References