Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 31214..31745 Replicon plasmid p5
Accession NZ_CP084278
Organism Caballeronia grimmiae strain Lep1A1

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag LDZ21_RS30955 Protein ID WP_011114071.1
Coordinates 31214..31495 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag LDZ21_RS30960 Protein ID WP_011114070.1
Coordinates 31482..31745 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ21_RS30945 27149..29353 - 2205 WP_047748384.1 EAL domain-containing protein -
LDZ21_RS30950 29430..30092 + 663 Protein_27 Tn3 family transposase -
LDZ21_RS30955 31214..31495 - 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
LDZ21_RS30960 31482..31745 - 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDZ21_RS30965 31918..32346 + 429 WP_011114069.1 antirestriction protein -
LDZ21_RS30970 32391..32609 + 219 WP_012478187.1 hypothetical protein -
LDZ21_RS30975 32621..33829 + 1209 WP_011114068.1 hypothetical protein -
LDZ21_RS30980 33846..34103 + 258 WP_011114067.1 transcriptional repressor KorC -
LDZ21_RS30985 34261..34497 + 237 WP_011114066.1 stable inheritance protein KleA -
LDZ21_RS30990 34706..35032 + 327 WP_011114065.1 KleE stable inheritance protein -
LDZ21_RS30995 35034..35363 + 330 WP_011114064.1 DUF2761 domain-containing protein -
LDZ21_RS31000 35470..35778 + 309 WP_011114062.1 transcriptional regulator KorA -
LDZ21_RS31005 35775..36539 + 765 WP_011114061.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..65095 65095
- flank IS/Tn - - 29370..30092 722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T218377 WP_011114071.1 NZ_CP084278:c31495-31214 [Caballeronia grimmiae]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T218377 NZ_CP115895:1650980-1651080 [Kalamiella piersonii]
GGCAAGGCGAAATCGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTACAAGAGCCATTTCCCTGGACCGAATACAGG
AATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT218377 WP_011114070.1 NZ_CP084278:c31745-31482 [Caballeronia grimmiae]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT218377 NZ_CP115895:c1651080-1650967 [Kalamiella piersonii]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGTAGAGCCGTGCGCTAAAAGTTGGCATTAA
TGCAGGCGATTTCGCCTTGCCAGTTAAGATTAGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References