Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2043131..2043747 Replicon chromosome
Accession NZ_CP084271
Organism Caballeronia grimmiae strain Lep1A1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LDZ21_RS09840 Protein ID WP_244793102.1
Coordinates 2043547..2043747 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LDZ21_RS09835 Protein ID WP_244793100.1
Coordinates 2043131..2043532 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ21_RS09805 2039043..2039252 - 210 WP_035960708.1 hypothetical protein -
LDZ21_RS09810 2039293..2039610 - 318 WP_035960707.1 DUF883 family protein -
LDZ21_RS09815 2039667..2040038 - 372 WP_244793096.1 hypothetical protein -
LDZ21_RS09820 2040657..2041724 + 1068 WP_244793098.1 sigma-54 dependent transcriptional regulator -
LDZ21_RS09825 2041990..2042544 + 555 WP_035960705.1 hypothetical protein -
LDZ21_RS09830 2042616..2043065 + 450 WP_244794809.1 hypothetical protein -
LDZ21_RS09835 2043131..2043532 - 402 WP_244793100.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDZ21_RS09840 2043547..2043747 - 201 WP_244793102.1 type II toxin-antitoxin system HicA family toxin Toxin
LDZ21_RS09845 2043919..2045289 - 1371 WP_035960701.1 nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein -
LDZ21_RS09850 2045302..2047053 - 1752 WP_244793104.1 ABC transporter permease subunit -
LDZ21_RS09855 2047551..2047826 + 276 WP_244793107.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7463.75 Da        Isoelectric Point: 11.8936

>T218376 WP_244793102.1 NZ_CP084271:c2043747-2043547 [Caballeronia grimmiae]
MDSSRLIRMLLDDGWHLVRIKGSHHHFKHGTRQGRLTVVHPKKDLPVGTVRAVLKGAGLLNRLYSS

Download         Length: 201 bp

>T218376 NZ_CP115895:c1398110-1397934 [Kalamiella piersonii]
TTGAGCAGTAAAGAGGTCATGAAGCTCCTCAGGGAGCATGGCTGGGTGTTTGTCCGCATCAGGGGAAGCCATCATCTATT
TGTTAAGCCTGGTAAAAATTATCATATAACGCTTCCTCATCCGGAAAAGGACCTGGCTGCCGGTACGTTAAGAAAAATCA
TGAAGCTGATTAACTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14699.59 Da        Isoelectric Point: 4.4383

>AT218376 WP_244793100.1 NZ_CP084271:c2043532-2043131 [Caballeronia grimmiae]
MEFAIAIHKEPESCYGVIVPNVPGVFSAGDTIDEALRNAREAIVAHVQTIIEEGEKVEINSTSIEELITDPDYEGAIWAF
VEVDLSKLDSKPERINISLPRFVLHKIDSYVEARHETRSGFLARAALEAIAHG

Download         Length: 402 bp

>AT218376 NZ_CP115895:c1397870-1397466 [Kalamiella piersonii]
ATGAGATTTCCGGTTTACTTGCACCAGACCGACTCGGGTAGCTATTCAGGTTTTGTACCTGATATTGAAGGCTGTTTTTT
TGCGGGCGAGACGGTAGATGACGCTATTCTTGATGCAGGCGCAGCGATAGATATTCATCTGGAAGCCCTGGCGGAGAGCG
GCATGCCCGTGCCTCACACCAAAGGCATGGCATTTTACTTAGAGAGTGACGAGTGCCAGGGCGGCATATGGGCCGTTATC
GATATTGATATCAGCAAGTATGAGGGTAAGGCGGTAAAGCTGAATATTACCCTGCCGCAAAGTCTTTTGACGCGCATCGA
CCGTTTCGTTGAATCACACCAGGAATTTAGCTCCAGAAGCGGTTTTTTAGCCGAGCTGGCGCGTCGCGAACTGGCAAAAA
GATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References