218374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2146256..2146871 Replicon chromosome
Accession NZ_CP084265
Organism Caballeronia sp. Lep1P3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LDZ27_RS10090 Protein ID WP_244813959.1
Coordinates 2146671..2146871 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LDZ27_RS10085 Protein ID WP_244813958.1
Coordinates 2146256..2146657 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ27_RS10055 2142210..2142437 - 228 WP_244813953.1 hypothetical protein -
LDZ27_RS10060 2142520..2142837 - 318 WP_244813954.1 DUF883 family protein -
LDZ27_RS10065 2142904..2143266 - 363 WP_244813955.1 hypothetical protein -
LDZ27_RS10070 2143806..2144870 + 1065 WP_244813956.1 sigma-54 dependent transcriptional regulator -
LDZ27_RS10075 2145162..2145665 + 504 WP_244816111.1 hypothetical protein -
LDZ27_RS10080 2145662..2146186 + 525 WP_244813957.1 hypothetical protein -
LDZ27_RS10085 2146256..2146657 - 402 WP_244813958.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LDZ27_RS10090 2146671..2146871 - 201 WP_244813959.1 type II toxin-antitoxin system HicA family toxin Toxin
LDZ27_RS10095 2147055..2148452 - 1398 WP_244813960.1 nitrate/sulfonate/bicarbonate ABC transporter ATP-binding protein -
LDZ27_RS10100 2148465..2150216 - 1752 WP_244813961.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7400.74 Da        Isoelectric Point: 12.0200

>T218374 WP_244813959.1 NZ_CP084265:c2146871-2146671 [Caballeronia sp. Lep1P3]
MDSSRLIRMLLDDGWKLARITGSHHHFKRAGRGVLVTVPHPRKDLSIGLVRAILKAAGLRDRLYAS

Download         Length: 201 bp

>T218374 NZ_CP115887:c2515218-2515111 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14515.52 Da        Isoelectric Point: 4.3653

>AT218374 WP_244813958.1 NZ_CP084265:c2146657-2146256 [Caballeronia sp. Lep1P3]
MEFAVAILKDRESSYGVIVPDIPGVFSAGDTVDEAIKNTREAIYGHVSVLIEEGMEVPLAASPIDELVANPDYAGAIWAF
VEVDLSKLDSKPERINISLPRFVLRKIDSYVEARHETRSGFLARVALEAIANG

Download         Length: 402 bp

>AT218374 NZ_CP115887:2515034-2515094 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References