Detailed information of TA system TA218373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 638702..639336
• Replicon: chromosome
• Accession: NZ_CP084260
• Organism: Caballeronia sp. SL2Y3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LDZ26_RS03000
• Protein ID: WP_244848095.1
• Coordinates: 638702..638881 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LDZ26_RS03005
• Protein ID: WP_244848096.1
• Coordinates: 638917..639336 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDZ26_RS02995	636353..638479	-	2127	WP_244848094.1	methionine--tRNA ligase	-
LDZ26_RS03000	638702..638881	+	180	WP_244848095.1	type II toxin-antitoxin system HicA family toxin	Toxin
LDZ26_RS03005	638917..639336	+	420	WP_244848096.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LDZ26_RS03010	639554..640210	-	657	WP_244848097.1	OmpA family protein	-
LDZ26_RS03015	640470..641558	+	1089	WP_244848098.1	iron-sulfur cluster carrier protein ApbC	-
LDZ26_RS03020	641678..642223	+	546	WP_244848099.1	superoxide dismutase family protein	-
LDZ26_RS03025	642383..642952	+	570	WP_014190693.1	dCTP deaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-66)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6916.07 Da
• Isoelectric Point: 11.4539

>T218373 WP_244848095.1 NZ_CP084260:638702-638881 [Caballeronia sp. SL2Y3]
MKYSEFKRWLRQQGAEFKPAKGSRFRVTLHGRTTIFPDHGSREIGTKLVEQIKKQLGLK

Nucleotide

• Length: 180 bp

>T218373 NZ_CP115887:c2488587-2488321 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15378.78 Da
• Isoelectric Point: 5.7777

>AT218373 WP_244848096.1 NZ_CP084260:638917-639336 [Caballeronia sp. SL2Y3]
MLSYPVNLELDTNNSYLVTFPDIPEAVSVGDDEQEALLNALDALESAIEIYFDEKRELPPPSKPRKGQAVVTLPALVVSK
VLLANEMVRQGVRKSELARRLNVHMPQVDRLLNPRHPSKLDAIEAALKSLGKRLSISLA

Nucleotide

• Length: 420 bp

>AT218373 NZ_CP115887:c2488838-2488587 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA