Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 16140..16777 Replicon plasmid p2
Accession NZ_CP084254
Organism Caballeronia sp. Sq4a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LDZ24_RS27655 Protein ID WP_248324898.1
Coordinates 16140..16541 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LDZ24_RS27660 Protein ID WP_248324899.1
Coordinates 16541..16777 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDZ24_RS27630 11268..12844 - 1577 Protein_10 IS21 family transposase -
LDZ24_RS27635 13126..14649 + 1524 WP_087129150.1 IS21 family transposase -
LDZ24_RS27640 14642..15442 + 801 WP_248324893.1 IS21-like element helper ATPase IstB -
LDZ24_RS27645 15763..15915 - 153 WP_248324894.1 hypothetical protein -
LDZ24_RS27650 15947..16123 - 177 WP_248324896.1 hypothetical protein -
LDZ24_RS27655 16140..16541 - 402 WP_248324898.1 type II toxin-antitoxin system VapC family toxin Toxin
LDZ24_RS27660 16541..16777 - 237 WP_248324899.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LDZ24_RS27665 17339..17511 + 173 Protein_17 DUF4148 domain-containing protein -
LDZ24_RS27670 17636..18873 + 1238 WP_248324902.1 IS3 family transposase -
LDZ24_RS27675 19311..21365 - 2055 WP_248324904.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74900 74900
- inside IScluster/Tn - - 10498..18873 8375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14734.06 Da        Isoelectric Point: 5.2054

>T218372 WP_248324898.1 NZ_CP084254:c16541-16140 [Caballeronia sp. Sq4a]
MPRFMLDTNMCIYLMKNQPEQVAKRFAECFVGDVVMSAITYAELEYGVAVCANPAKERRTLAALIEDIPVAPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVALVTNNTKDFVSYPGVKLENWLSD

Download         Length: 402 bp

>T218372 NZ_CP115887:c2228504-2228400 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTAATCAAGGCCATAAAAAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8897.09 Da        Isoelectric Point: 8.6851

>AT218372 WP_248324899.1 NZ_CP084254:c16777-16541 [Caballeronia sp. Sq4a]
VQITRVFRNGNSQAVRIPADLAYERSDLELEIERVGDEIRIRPARRPLAGVLKKFAKFSPDFMAQGRGEQEQAEREGL

Download         Length: 237 bp

>AT218372 NZ_CP115887:2228302-2228344 [Staphylococcus aureus]
CAGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References