Detailed information of TA system TA218370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 683505..684139
• Replicon: chromosome
• Accession: NZ_CP084250
• Organism: Caballeronia sp. Sq4a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LDZ24_RS03150
• Protein ID: WP_248321540.1
• Coordinates: 683505..683684 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LDZ24_RS03155
• Protein ID: WP_248321542.1
• Coordinates: 683720..684139 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDZ24_RS03135	678759..680075	+	1317	WP_248321535.1	MFS transporter	-
LDZ24_RS03140	680072..681016	+	945	WP_248321537.1	amidohydrolase family protein	-
LDZ24_RS03145	681144..683282	-	2139	WP_248321538.1	methionine--tRNA ligase	-
LDZ24_RS03150	683505..683684	+	180	WP_248321540.1	type II toxin-antitoxin system HicA family toxin	Toxin
LDZ24_RS03155	683720..684139	+	420	WP_248321542.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LDZ24_RS03160	684367..685023	-	657	WP_248321544.1	OmpA family protein	-
LDZ24_RS03165	685283..686371	+	1089	WP_175939706.1	iron-sulfur cluster carrier protein ApbC	-
LDZ24_RS03170	686491..687036	+	546	WP_175939707.1	superoxide dismutase family protein	-
LDZ24_RS03175	687196..687765	+	570	WP_014190693.1	dCTP deaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-66)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6897.03 Da
• Isoelectric Point: 11.2257

>T218370 WP_248321540.1 NZ_CP084250:683505-683684 [Caballeronia sp. Sq4a]
MKYSEFKRWLRQQGAEFKPAKGSHFRVTLHGRTTIFPDHGSREIGTKLVEQIKKQLGLK

Nucleotide

• Length: 180 bp

>T218370 NZ_CP115887:c2151740-2151378 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15377.84 Da
• Isoelectric Point: 7.2043

>AT218370 WP_248321542.1 NZ_CP084250:683720-684139 [Caballeronia sp. Sq4a]
MLSYPVNLELDTNNSYLVTFPDIPEAVSVGDDKEEALLNALDALESAIEIYFNEKRELPPPSKPRKGQAVVTLPALVVSK
VLLANEMVRQGVRKSELARRLNVHMPQVDRLLNPRHPSKLDAIEAALKSLGKRLSISLA

Nucleotide

• Length: 420 bp

>AT218370 NZ_CP115887:c2151907-2151737 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA