Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/-
Location 2081880..2082577 Replicon chromosome
Accession NZ_CP084248
Organism Enterococcus lactis strain DH9003

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag K9N64_RS12560 Protein ID WP_225479451.1
Coordinates 2082158..2082577 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag K9N64_RS12555 Protein ID WP_002316334.1
Coordinates 2081880..2082134 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9N64_RS12525 (K9N64_12505) 2077326..2078492 - 1167 WP_002292137.1 radical SAM family heme chaperone HemW -
K9N64_RS12530 (K9N64_12510) 2078508..2078735 - 228 Protein_1947 hypothetical protein -
K9N64_RS12535 (K9N64_12515) 2078987..2079253 - 267 WP_002292138.1 type II toxin-antitoxin system RelE/ParE family toxin -
K9N64_RS12540 (K9N64_12520) 2079250..2079480 - 231 WP_002292139.1 DUF6290 family protein -
K9N64_RS12545 (K9N64_12525) 2079972..2080637 - 666 WP_002292140.1 hypothetical protein -
K9N64_RS12550 (K9N64_12530) 2080774..2081733 - 960 WP_000222573.1 IS30 family transposase -
K9N64_RS12555 (K9N64_12535) 2081880..2082134 + 255 WP_002316334.1 hypothetical protein Antitoxin
K9N64_RS12560 (K9N64_12540) 2082158..2082577 + 420 WP_225479451.1 toxin Toxin
K9N64_RS12565 (K9N64_12545) 2082809..2083567 - 759 WP_167779246.1 restriction endonuclease -
K9N64_RS12570 2083759..2084013 + 255 WP_087063755.1 toxin -
K9N64_RS12575 (K9N64_12550) 2084066..2084497 - 432 WP_002342168.1 N-6 DNA methylase -
K9N64_RS12580 (K9N64_12555) 2084707..2084868 - 162 WP_002342167.1 hypothetical protein -
K9N64_RS12585 (K9N64_12560) 2084861..2085529 - 669 WP_225479172.1 zeta toxin family protein -
K9N64_RS12590 (K9N64_12565) 2086254..2086882 + 629 Protein_1959 glutamine amidotransferase -
K9N64_RS12595 (K9N64_12570) 2087053..2087496 - 444 WP_002345979.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2080774..2081733 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16460.51 Da        Isoelectric Point: 4.6731

>T218369 WP_225479451.1 NZ_CP084248:2082158-2082577 [Enterococcus lactis]
VISEGLYFEAADLANELSEEVSYYCSKKMEHVKCYDIENYVNEVEDVEFIDYDFKDNLSKKMLGSITKVHGEIIITTNQH
LMLERKNFTKMHEIIHYYKDVPYLGESHAFSDMILEDTYLPEDYKKTSSKYRCQYPHGE

Download         Length: 420 bp

>T218369 NZ_CP115887:c2050354-2050178 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9799.93 Da        Isoelectric Point: 4.2290

>AT218369 WP_002316334.1 NZ_CP084248:2081880-2082134 [Enterococcus lactis]
MSNYQLVTVIADFFNVSTDFLLNRTSDPTPPKRSEEDQLGDSILSHFRLNTADMEVEDIEELEEELNEYMDFLVQRAKAK
KNKK

Download         Length: 255 bp

>AT218369 NZ_CP115887:2050055-2050110 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References