Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Txe-Axe/YoeB-RelB |
| Location | 6715..7234 | Replicon | plasmid pY3-3 |
| Accession | NZ_CP084246 | ||
| Organism | Enterococcus lactis strain DH9003 | ||
Toxin (Protein)
| Gene name | Txe | Uniprot ID | - |
| Locus tag | K9N64_RS00450 | Protein ID | WP_104661364.1 |
| Coordinates | 6977..7234 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | Axe | Uniprot ID | - |
| Locus tag | K9N64_RS00445 | Protein ID | WP_104661363.1 |
| Coordinates | 6715..6984 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9N64_RS00435 (K9N64_00435) | 2606..4096 | - | 1491 | WP_225479002.1 | IS5 family transposase | - |
| K9N64_RS00440 (K9N64_00440) | 4358..6163 | - | 1806 | WP_225479003.1 | AIPR family protein | - |
| K9N64_RS00445 (K9N64_00445) | 6715..6984 | + | 270 | WP_104661363.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K9N64_RS00450 (K9N64_00450) | 6977..7234 | + | 258 | WP_104661364.1 | Txe/YoeB family addiction module toxin | Toxin |
| K9N64_RS00455 (K9N64_00455) | 7519..7686 | - | 168 | WP_225479004.1 | hypothetical protein | - |
| K9N64_RS00460 (K9N64_00460) | 7852..8655 | - | 804 | WP_225479005.1 | AAA family ATPase | - |
| K9N64_RS00465 (K9N64_00465) | 8648..9436 | - | 789 | Protein_9 | Mu transposase C-terminal domain-containing protein | - |
| K9N64_RS00470 (K9N64_00470) | 9493..10173 | - | 681 | WP_225479006.1 | IS6-like element IS1216 family transposase | - |
| K9N64_RS00475 (K9N64_00475) | 11360..12172 | + | 813 | WP_225479007.1 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | tet(S) / str / cat | - | 1..63644 | 63644 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10272.65 Da Isoelectric Point: 9.2523
>T218365 WP_104661364.1 NZ_CP084246:6977-7234 [Enterococcus lactis]
MIKAWSDDAWNDYIYWHEQGNKMNIKKINKLIKDIDRTPFSGIGKPEPLKHDLSGKWSRRITDEHRLIYAVKDETIYFYS
ARDHY
MIKAWSDDAWNDYIYWHEQGNKMNIKKINKLIKDIDRTPFSGIGKPEPLKHDLSGKWSRRITDEHRLIYAVKDETIYFYS
ARDHY
Download Length: 258 bp
>T218365 NZ_CP115887:c1525955-1525779 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGGTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10404.52 Da Isoelectric Point: 4.1555
>AT218365 WP_104661363.1 NZ_CP084246:6715-6984 [Enterococcus lactis]
MEAVAYSNFRQNLKSYMKQVNEDADTLIVTSKDIEDTVVVLSKRDYDAMQETLRVLSNNYVMDKIRRGDQQFESGNFTTR
ELLEVEEDD
MEAVAYSNFRQNLKSYMKQVNEDADTLIVTSKDIEDTVVVLSKRDYDAMQETLRVLSNNYVMDKIRRGDQQFESGNFTTR
ELLEVEEDD
Download Length: 270 bp
>AT218365 NZ_CP115887:1525656-1525711 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|