Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3996689..3997308 Replicon chromosome
Accession NZ_CP084241
Organism Klebsiella pneumoniae strain T877

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LDH71_RS19570 Protein ID WP_002892050.1
Coordinates 3997090..3997308 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LDH71_RS19565 Protein ID WP_002892066.1
Coordinates 3996689..3997063 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH71_RS19555 (3991841) 3991841..3993034 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDH71_RS19560 (3993057) 3993057..3996203 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LDH71_RS19565 (3996689) 3996689..3997063 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LDH71_RS19570 (3997090) 3997090..3997308 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LDH71_RS19575 (3997467) 3997467..3998033 + 567 WP_002892030.1 maltose O-acetyltransferase -
LDH71_RS19580 (3998005) 3998005..3998145 - 141 WP_004147370.1 hypothetical protein -
LDH71_RS19585 (3998166) 3998166..3998636 + 471 WP_002892026.1 YlaC family protein -
LDH71_RS19590 (3998611) 3998611..4000062 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LDH71_RS19595 (4000163) 4000163..4000861 + 699 WP_002892021.1 GNAT family protein -
LDH71_RS19600 (4000858) 4000858..4000998 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LDH71_RS19605 (4000998) 4000998..4001261 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218360 WP_002892050.1 NZ_CP084241:3997090-3997308 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T218360 NZ_CP115874:3537285-3537578 [Enterobacter hormaechei subsp. steigerwaltii]
ATCATTTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATCCCTTTGAATCTGGAAAC
AGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATATGTATG
AAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGGTCAGAG
GGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT218360 WP_002892066.1 NZ_CP084241:3996689-3997063 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT218360 NZ_CP115874:3537589-3537954 [Enterobacter hormaechei subsp. steigerwaltii]
ATGACACTTCAACAGGCACTCCGCAAACCCTCCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCATTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAACCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References