Detailed information of TA system TA218358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2571776..2573364
• Replicon: chromosome
• Accession: NZ_CP084241
• Organism: Klebsiella pneumoniae strain T877

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LDH71_RS12530
• Protein ID: WP_004184027.1
• Coordinates: 2571776..2573098 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LDH71_RS12535
• Protein ID: WP_004176198.1
• Coordinates: 2573098..2573364 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDH71_RS12515 (2566832)	2566832..2569333	+	2502	WP_032439971.1	fimbria/pilus outer membrane usher protein	-
LDH71_RS12520 (2569321)	2569321..2570325	+	1005	WP_016946380.1	fimbrial protein	-
LDH71_RS12525 (2570467)	2570467..2571759	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LDH71_RS12530 (2571776)	2571776..2573098	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
LDH71_RS12535 (2573098)	2573098..2573364	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LDH71_RS12540 (2573630)	2573630..2573956	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
LDH71_RS12545 (2573953)	2573953..2574453	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LDH71_RS12550 (2574431)	2574431..2575810	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LDH71_RS12555 (2576156)	2576156..2577310	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LDH71_RS12560 (2577291)	2577291..2578214	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T218358 WP_004184027.1 NZ_CP084241:c2573098-2571776 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T218358 NZ_CP115874:c2882582-2882229 [Enterobacter hormaechei subsp. steigerwaltii]
GTGTGGGCGGTTAAAACTACGGACAGGTTTGACGACTGGTTCACCTCATTAAACGATAGCGAGAGAGCCAGCGTACTGGC
CGCGCTACTTGTTTTGCGGGAGAGGGGACCGGGTCTGTCCAGACCGTATGCCGATACGCTGAAAGGCTCCCGCCACAGCA
ACATGAAAGAGTTGCGTATCCAGAGTAAGGGTGATCCGCTGAGGGCATTTTTCGCTTTCGATCCGAACCGTACGGGTATT
GTACTGTGTGCGGGCAATAAGGTCGGTAATGAAAGGCGATTTTACGATGAGATGCTCCTCGTTGCGGATCGGGAATACAC
TCGCTGGCTGAACACATTAAAAGAGAGGAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT218358 WP_004176198.1 NZ_CP084241:c2573364-2573098 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT218358 NZ_CP115874:c2882224-2881922 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGGCAGAACCCTGGAGCAGCTTATTGCAGATGAAAAACCTGAGGTTGTTGCCAGCGCACAGGCAATGGCAACGGATAT
TTTGCTCAATATCCATCTGGCCGAGTTACGTGAAAAAGTGCAAAAAACGCAGGTAGATATGGCCAGGGCGTTGGGTATTA
AACAACCTACTGTCGCCGTCATGGAAAAGGCAGGACGCGATATTAAGCTTTCTTCTTTGAAACGCTACGTTGAGGCCGCC
GGAGGGAAGCTACGGCTGGATGTAGAACTACCCGATGGTTCTCATTACGAGTTTGTGTTGTAA