218344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1859388..1859856 Replicon chromosome
Accession NZ_CP084235
Organism Staphylococcus haemolyticus strain SE2.14

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag RES5_RS09160 Protein ID WP_011276326.1
Coordinates 1859668..1859856 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A318R523
Locus tag RES5_RS09155 Protein ID WP_016931010.1
Coordinates 1859388..1859645 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RES5_RS09120 (RES5_009120) 1854551..1855276 - 726 WP_085059890.1 type I 3-dehydroquinate dehydratase -
RES5_RS09125 (RES5_009125) 1855439..1855861 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
RES5_RS09130 (RES5_009130) 1856138..1856629 + 492 WP_016931014.1 GNAT family N-acetyltransferase -
RES5_RS09135 (RES5_009135) 1856760..1857377 + 618 WP_161511439.1 LysE family transporter -
RES5_RS09140 (RES5_009140) 1857565..1858173 - 609 WP_161511657.1 histidine phosphatase family protein -
RES5_RS09145 (RES5_009145) 1858400..1858642 + 243 WP_011276324.1 hypothetical protein -
RES5_RS09150 (RES5_009150) 1858634..1858837 - 204 WP_016931011.1 sterile alpha motif-like domain-containing protein -
RES5_RS09155 (RES5_009155) 1859388..1859645 + 258 WP_016931010.1 hypothetical protein Antitoxin
RES5_RS09160 (RES5_009160) 1859668..1859856 + 189 WP_011276326.1 hypothetical protein Toxin
RES5_RS09165 (RES5_009165) 1859974..1860555 + 582 WP_016931009.1 lipoprotein N-acylation protein LnsA -
RES5_RS09170 (RES5_009170) 1860603..1860839 - 237 WP_016931008.1 hypothetical protein -
RES5_RS09175 (RES5_009175) 1861009..1861755 + 747 WP_053024266.1 membrane lipoprotein lipid attachment site-containing protein -
RES5_RS09180 (RES5_009180) 1861825..1862433 - 609 WP_053024265.1 GNAT family N-acetyltransferase -
RES5_RS09185 (RES5_009185) 1862570..1863316 + 747 WP_016931005.1 poly-gamma-glutamate hydrolase family protein -
RES5_RS09190 (RES5_009190) 1863392..1863679 + 288 WP_016931004.1 hypothetical protein -
RES5_RS09195 (RES5_009195) 1863919..1864143 + 225 WP_016931003.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(6-63)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T218344 WP_011276326.1 NZ_CP084235:1859668-1859856 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T218344 NZ_CP115843:242067-242360 [Agrobacterium fabacearum]
ATGCCATTTAGCCTATCTGTCCAAGCGGAAGAGGATATTATTTCCATTGCAGAAGAATGCATCCGCATCTTCGGAGCACT
AGTCGCCAGACAATATCACGATGAGCTTTTTGCCTTGCTCGAGCTCATCGCCACCAACCCAAGAATGGCACGCGAACGCC
ACGAGATTTCTCCTCCTGTCAGGATCCATCCTTTCAAGGCTCACCTTGTCGTGTACCGCATCATTGAAGACGGGAGCGTA
TTCGTCATCCGCATACGGCACGGCCATGAAGATTGGGCGGGAAATTCTTTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9864.88 Da        Isoelectric Point: 4.1050

>AT218344 WP_016931010.1 NZ_CP084235:1859388-1859645 [Staphylococcus haemolyticus]
MNNNKIFWINIFITLLFLGFNIIVTYNAELDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIAMLLYYIYPI
VYTFF

Download         Length: 258 bp

>AT218344 NZ_CP115843:241813-242067 [Agrobacterium fabacearum]
ATGGCGACGATGAATGTATCCCTGCCAGACCCCATGAAAGATTGGGTTGAAGCACAGGCCAAGACTGGTCGATACTCGAA
TGCGAGCGATTATGTCCGGGACCTGATCCGCAGAGACCAAGCGCGTACGGATAAGATTGCCGAGATGCAGCGATTTGTCG
ACGACGGGATCAGAAGCGGAGTTGGGAGCCGTTCAACGGAAGAGTTGTTTGCTTTAGCCACTTCTCGAGCTGACATCAGC
CGCGGACGCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A318R523

References