218342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820386..820918 Replicon chromosome
Accession NZ_CP084235
Organism Staphylococcus haemolyticus strain SE2.14

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag RES5_RS04025 Protein ID WP_011275272.1
Coordinates 820553..820918 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K0A6Q6
Locus tag RES5_RS04020 Protein ID WP_037538759.1
Coordinates 820386..820556 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RES5_RS03995 (RES5_003995) 816172..816651 + 480 WP_161511379.1 PH domain-containing protein -
RES5_RS04000 (RES5_004000) 816644..818167 + 1524 WP_161511380.1 PH domain-containing protein -
RES5_RS04005 (RES5_004005) 818160..818687 + 528 WP_037551985.1 PH domain-containing protein -
RES5_RS04010 (RES5_004010) 818697..819056 + 360 WP_037551987.1 holo-ACP synthase -
RES5_RS04015 (RES5_004015) 819152..820300 + 1149 WP_161511381.1 alanine racemase -
RES5_RS04020 (RES5_004020) 820386..820556 + 171 WP_037538759.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RES5_RS04025 (RES5_004025) 820553..820918 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RES5_RS04030 (RES5_004030) 821225..822226 + 1002 WP_085060547.1 PP2C family protein-serine/threonine phosphatase -
RES5_RS04035 (RES5_004035) 822325..822651 + 327 WP_011275274.1 anti-sigma factor antagonist -
RES5_RS04040 (RES5_004040) 822680..823132 + 453 WP_052071620.1 anti-sigma B factor RsbW -
RES5_RS04045 (RES5_004045) 823107..823877 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T218342 WP_011275272.1 NZ_CP084235:820553-820918 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T218342 NZ_CP115841:c330629-330360 [Agrobacterium fabacearum]
TTGACCTGGAAAATTGAATTTCAGCAGCGAGCCGTCAAACAGCTTGGAAAGTTGGCAAAGCAGGACGCGAACCGCATCGT
TTCTTTTCTGGCGGATCGGGTCGTCCAGGACGACAATCCCCGCCAGACAGGTGCCGCCCTGCAAGGCTCAGAACTCGGCA
GCTTCTGGCGTTACCGGGTAGGCGATTACTGTATCATCTGCGATATACAGGACCACAAGCTTGTCGTGCTGGTGGTGGAA
ATTGGCCATCGCCGCGAAATTTACCGTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT218342 WP_037538759.1 NZ_CP084235:820386-820556 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYIISNYKSE

Download         Length: 171 bp

>AT218342 NZ_CP115841:c330846-330613 [Agrobacterium fabacearum]
ATGAGCAAACAGACTGCCATCCGCCTGCCGGACGAGACCTATGAACGGCTGAAAGCGCTTTCCGAGCGCACGGGCCGTAC
GTCCGCATACTATATCCGCGAGGCGATTGAGAAACATATTGAGGATATGGAAGATCTCTATCTAGCCGAAGAGGCGACGC
GACAGCGCATTGCCAATAAAGAGCGCACCTATAATCTGGAAGAAGTGATGCGCGATCTTGACCTGGAAAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2K0A6Q6

References