Detailed information of TA system TA218341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809370..809881
• Replicon: chromosome
• Accession: NZ_CP084235
• Organism: Staphylococcus haemolyticus strain SE2.14

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: A0A2K0A6P2
• Locus tag: RES5_RS03965
• Protein ID: WP_037551971.1
• Coordinates: 809675..809881 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: RES5_RS03960
• Protein ID: WP_037538785.1
• Coordinates: 809370..809663 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RES5_RS03935 (RES5_003935)	804497..805288	+	792	WP_161511383.1	hydroxyethylthiazole kinase	-
RES5_RS03940 (RES5_003940)	805290..805928	+	639	WP_085060557.1	thiamine phosphate synthase	-
RES5_RS03945 (RES5_003945)	806017..806892	+	876	WP_161511375.1	membrane protein insertase YidC	-
RES5_RS03950 (RES5_003950)	806957..807598	-	642	WP_085060556.1	HD domain-containing protein	-
RES5_RS03955 (RES5_003955)	807698..809182	-	1485	WP_161511376.1	cardiolipin synthase	-
RES5_RS03960 (RES5_003960)	809370..809663	+	294	WP_037538785.1	copper-sensing transcriptional repressor CsoR	Antitoxin
RES5_RS03965 (RES5_003965)	809675..809881	+	207	WP_037551971.1	heavy-metal-associated domain-containing protein	Toxin
RES5_RS03970 (RES5_003970)	809989..810126	+	138	WP_011275260.1	Lmo0850 family protein	-
RES5_RS03975 (RES5_003975)	810175..811365	-	1191	WP_037551974.1	FtsW/RodA/SpoVE family cell cycle protein	-
RES5_RS03980 (RES5_003980)	811783..812853	+	1071	WP_053025522.1	D-alanine--D-alanine ligase	-
RES5_RS03985 (RES5_003985)	812869..814224	+	1356	WP_161511377.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7841.79 Da
• Isoelectric Point: 4.0742

>T218341 WP_037551971.1 NZ_CP084235:809675-809881 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISFETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T218341 NZ_CP115839:40354-40689 [Klebsiella pneumoniae]
ATGGAATACTACGAATTTGTAGAAACCTCTGTGTTCACGCGAGAGATGAAAACTCTACTCAGTGATGATGAATACAAAGA
GTTTCAAACGTTCCTCATCGAGAACCCGGAGGCGGGTGATCTGATTGTAGGAACTGGCGGTTGTCGCAAGGTTAGATGGT
CACGGCAGGGAACAGGTAAAAGTTCAGGTGTCCGTGCTATTTACTACTTCTACAACCCGGCAGGGCGCTTATACATGCTT
ATCATCTATCCAAAGAGTGAGAAGGATAGTTTGACAGCAGCAGAGAAAAACCAGCTCAAAGCGGTTGTAGCGGGTTTTAA
AGGTGAAGAGGGCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11236.86 Da
• Isoelectric Point: 6.6364

>AT218341 WP_037538785.1 NZ_CP084235:809370-809663 [Staphylococcus haemolyticus]
MNNHENAHHSEQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT218341 NZ_CP115839:40694-40984 [Klebsiella pneumoniae]
ATGCGTAAAGAGCTTTTTGATGATCTGATTGCTTCTGCTAAAGAAGCTGTAGAAATCCATCAGGGTTTACGTGAGCCAGC
TCGCGTGACCCGTTTTGAACGTCCAGATGTAAAAGCTATACGGGCTAAGGTTCATATGAAACAAGATGATTTTGCCAGCC
TGATCGGGGTTAGCTCTTCTCTTGTTCAATCATGGGAACAAGGGTTAAGAACTCCGGCAGGTGCAGCGTTAAAGCTGTTG
CGTGTCATCGAGCGTAAACCTGAATTTGTTCAGGAACTACGTGAAGCATAA

Structures

Toxin

• AlphaFold DB: A0A2K0A6P2