Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1745393..1745984 Replicon chromosome
Accession NC_008751
Organism Desulfovibrio vulgaris DP4

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3A7J7
Locus tag DVUL_RS07450 Protein ID WP_011792259.1
Coordinates 1745670..1745984 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3A8P1
Locus tag DVUL_RS07445 Protein ID WP_011792258.1
Coordinates 1745393..1745686 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVUL_RS07415 1740504..1740944 + 441 WP_010938937.1 lipoprotein -
DVUL_RS07420 1741018..1742256 + 1239 WP_011792255.1 diaminopimelate decarboxylase -
DVUL_RS07425 1742482..1742925 - 444 WP_011792256.1 arsenate reductase ArsC -
DVUL_RS07430 1743084..1743428 + 345 WP_010938934.1 metalloregulator ArsR/SmtB family transcription factor -
DVUL_RS07435 1743434..1744549 + 1116 WP_011792257.1 permease -
DVUL_RS07445 1745393..1745686 - 294 WP_011792258.1 putative addiction module antidote protein Antitoxin
DVUL_RS07450 1745670..1745984 - 315 WP_011792259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DVUL_RS07455 1746207..1746446 - 240 WP_011792260.1 hypothetical protein -
DVUL_RS17410 1746744..1747436 + 693 WP_150100234.1 hypothetical protein -
DVUL_RS07460 1747426..1748505 - 1080 WP_011792261.1 hypothetical protein -
DVUL_RS07465 1748490..1749176 - 687 WP_011792262.1 hypothetical protein -
DVUL_RS07470 1749173..1749733 - 561 WP_011792263.1 hypothetical protein -
DVUL_RS07475 1749730..1750665 - 936 WP_011792264.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1743434..1789655 46221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11683.30 Da        Isoelectric Point: 8.5040

>T21834 WP_011792259.1 NC_008751:c1745984-1745670 [Desulfovibrio vulgaris DP4]
MNTFFRTDVFAKWLSGLKDMAGRARILVRIRSAEAGNFGDCEPVGEGVSEMRIHTGPGYRVYFTRRGETVYLLLAGGDKS
SQKRDIVLAKKLARELEDSHDQDC

Download         Length: 315 bp

>T21834 NC_008751:c1745984-1745670 [Desulfovibrio vulgaris DP4]
ATGAACACGTTCTTCCGCACGGATGTTTTCGCCAAGTGGCTCAGTGGCCTCAAAGACATGGCGGGAAGGGCCAGAATCCT
TGTGCGGATACGGTCGGCAGAGGCAGGCAACTTCGGTGATTGCGAACCGGTAGGCGAGGGCGTCTCCGAGATGCGCATTC
ACACGGGACCGGGGTATCGGGTCTACTTCACTCGCCGGGGCGAGACGGTCTACCTGCTGCTCGCAGGTGGCGACAAGTCC
AGCCAGAAGCGCGACATCGTGCTGGCCAAGAAGCTGGCGCGAGAATTGGAGGATAGCCATGACCAAGATTGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10315.86 Da        Isoelectric Point: 4.8011

>AT21834 WP_011792258.1 NC_008751:c1745686-1745393 [Desulfovibrio vulgaris DP4]
MTKIARFDAAEFLDSEEAIAEYLTAALEDPNPDVFLAAVADVAKARGMSQLAKDAGLGRESLYKALTPGAQPRYSTVRKL
LDAMGVTLEAKPKVAAC

Download         Length: 294 bp

>AT21834 NC_008751:c1745686-1745393 [Desulfovibrio vulgaris DP4]
ATGACCAAGATTGCTAGATTTGACGCCGCCGAGTTCCTCGATAGCGAAGAAGCCATCGCCGAGTACCTCACGGCAGCACT
TGAAGATCCGAATCCGGACGTGTTCCTCGCAGCGGTTGCCGATGTGGCGAAAGCCCGAGGCATGAGCCAGCTTGCCAAGG
ACGCGGGCCTCGGGCGTGAAAGCCTGTACAAGGCCCTCACCCCTGGAGCGCAGCCACGCTACAGCACCGTCAGAAAGCTG
CTGGATGCCATGGGCGTCACGCTTGAGGCCAAGCCCAAGGTCGCTGCCTGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3A7J7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3A8P1

References