Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1859427..1859895 | Replicon | chromosome |
| Accession | NZ_CP084229 | ||
| Organism | Staphylococcus haemolyticus strain SE3.8 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q4L4Q4 |
| Locus tag | RES6_RS09150 | Protein ID | WP_011276326.1 |
| Coordinates | 1859707..1859895 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | A0A318R523 |
| Locus tag | RES6_RS09145 | Protein ID | WP_016931010.1 |
| Coordinates | 1859427..1859684 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RES6_RS09110 (RES6_009110) | 1854590..1855315 | - | 726 | WP_085059890.1 | type I 3-dehydroquinate dehydratase | - |
| RES6_RS09115 (RES6_009115) | 1855478..1855900 | + | 423 | WP_016931015.1 | organic hydroperoxide resistance protein | - |
| RES6_RS09120 (RES6_009120) | 1856177..1856668 | + | 492 | WP_016931014.1 | GNAT family N-acetyltransferase | - |
| RES6_RS09125 (RES6_009125) | 1856799..1857416 | + | 618 | WP_161511439.1 | LysE family transporter | - |
| RES6_RS09130 (RES6_009130) | 1857604..1858212 | - | 609 | WP_161511657.1 | histidine phosphatase family protein | - |
| RES6_RS09135 (RES6_009135) | 1858439..1858681 | + | 243 | WP_011276324.1 | hypothetical protein | - |
| RES6_RS09140 (RES6_009140) | 1858673..1858876 | - | 204 | WP_016931011.1 | sterile alpha motif-like domain-containing protein | - |
| RES6_RS09145 (RES6_009145) | 1859427..1859684 | + | 258 | WP_016931010.1 | hypothetical protein | Antitoxin |
| RES6_RS09150 (RES6_009150) | 1859707..1859895 | + | 189 | WP_011276326.1 | hypothetical protein | Toxin |
| RES6_RS09155 (RES6_009155) | 1860013..1860594 | + | 582 | WP_016931009.1 | lipoprotein N-acylation protein LnsA | - |
| RES6_RS09160 (RES6_009160) | 1860642..1860878 | - | 237 | WP_016931008.1 | hypothetical protein | - |
| RES6_RS09165 (RES6_009165) | 1861048..1861794 | + | 747 | WP_053024266.1 | membrane lipoprotein lipid attachment site-containing protein | - |
| RES6_RS09170 (RES6_009170) | 1861864..1862472 | - | 609 | WP_053024265.1 | GNAT family N-acetyltransferase | - |
| RES6_RS09175 (RES6_009175) | 1862609..1863355 | + | 747 | WP_016931005.1 | poly-gamma-glutamate hydrolase family protein | - |
| RES6_RS09180 (RES6_009180) | 1863431..1863718 | + | 288 | WP_016931004.1 | hypothetical protein | - |
| RES6_RS09185 (RES6_009185) | 1863958..1864182 | + | 225 | WP_016931003.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7110.80 Da Isoelectric Point: 9.6269
>T218337 WP_011276326.1 NZ_CP084229:1859707-1859895 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL
Download Length: 189 bp
>T218337 NZ_CP115837:c4618548-4618216 [Klebsiella pneumoniae]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9864.88 Da Isoelectric Point: 4.1050
>AT218337 WP_016931010.1 NZ_CP084229:1859427-1859684 [Staphylococcus haemolyticus]
MNNNKIFWINIFITLLFLGFNIIVTYNAELDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIAMLLYYIYPI
VYTFF
MNNNKIFWINIFITLLFLGFNIIVTYNAELDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIAMLLYYIYPI
VYTFF
Download Length: 258 bp
>AT218337 NZ_CP115837:c4618886-4618569 [Klebsiella pneumoniae]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A1KAB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A318R523 |